Can tonsillectomy modify the innate and adaptive immunity pathways involved in IgA nephropathy?

Luca Vergano; Elisa Loiacono; Roberto Albera; Rosanna Coppo; Roberta Camilla; Licia Peruzzi; Alessandro Amore; Maria Elena Donadio; Federica Chiale; Alberto Boido; Filippo Mariano; Gianna Mazzucco; Sara Ravera; Giovanni Cancarini; Riccardo Magistroni; Giulietta Beltrame; Cristiana Rollino; Piero Stratta; Marco Quaglia; Roberto Bergia; Raffaella Cravero; Stefano Cusinato; Luisa Benozzi; Silvana Savoldi; Carola Licata

doi:10.1007/s40620-014-0086-8

Can tonsillectomy modify the innate and adaptive immunity pathways involved in IgA nephropathy?

Luca Vergano, Elisa Loiacono, Roberto Albera, Rosanna Coppo, Roberta Camilla, Licia Peruzzi, Alessandro Amore, Maria Elena Donadio, Federica Chiale, Alberto Boido, Filippo Mariano, Gianna Mazzucco, Sara Ravera, Giovanni Cancarini, Riccardo Magistroni, Giulietta Beltrame, Cristiana Rollino, Piero Stratta, Marco Quaglia, Roberto BergiaRaffaella Cravero, Stefano Cusinato, Luisa Benozzi, Silvana Savoldi, Carola Licata

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

The benefits of tonsillectomy in IgA nephropathy (IgAN) are still debated. Tonsillectomy may remove pathogen sources and reduce the mucosal associated lymphoid tissue (MALT), limiting degalactosylated IgA1 (deGal-IgA1) production, which is considered to be the initiating pathogenetic event leading to IgA glomerular deposition. In the European network VALIGA, 62/1147 IgAN patients underwent tonsillectomy (TxIgAN). In a cross-sectional study 15 of these patients were tested and compared to 45 non-tonsillectomized IgAN (no-TxIgAN) and healthy controls (HC) regarding levels of deGal-IgA1, and markers of innate immunity and oxidative stress, including toll-like receptors (TLR)2, 3, 4 and 9 mRNAs, proteasome (PS) and immunoproteasome (iPS) mRNAs in peripheral blood mononuclear cells (PBMC), and advanced oxidation protein products (AOPP). Levels of deGal-IgA1 were lower in TxIgAN than in no-TxIgAN (p = 0.015), but higher than in HC (p = 0.003). TLR mRNAs were more expressed in TxIgAN than in HC (TLR4, p = 0.021; TLR9, p = 0.027), and higher in TxIgAN than in no-TxIgAN (p ≤ 0.001 for TLR2, 4, 9). A switch from PS to iPS was detected in PBMC of TxIgAN in comparison to HC and it was higher than in no-TxIgAN [large multifunctional peptidase (LMP)2/β1, p = 0.039; LPM7/β5, p

Original language	English
Pages (from-to)	51-58
Number of pages	8
Journal	Journal of Nephrology
Volume	28
Issue number	1
DOIs	https://doi.org/10.1007/s40620-014-0086-8
Publication status	Published - 2014

Keywords

Aberrantly glycosylated IgA
IgA nephropathy
Immunoproteasomes
Innate immunity
Oxidative stress
Toll-like receptors
Tonsillectomy

ASJC Scopus subject areas

Nephrology

Access to Document

10.1007/s40620-014-0086-8

Cite this

Vergano, L., Loiacono, E., Albera, R., Coppo, R., Camilla, R., Peruzzi, L., Amore, A., Donadio, M. E., Chiale, F., Boido, A., Mariano, F., Mazzucco, G., Ravera, S., Cancarini, G., Magistroni, R., Beltrame, G., Rollino, C., Stratta, P., Quaglia, M., ... Licata, C. (2014). Can tonsillectomy modify the innate and adaptive immunity pathways involved in IgA nephropathy? Journal of Nephrology, 28(1), 51-58. https://doi.org/10.1007/s40620-014-0086-8

Vergano, L, Loiacono, E, Albera, R, Coppo, R, Camilla, R, Peruzzi, L, Amore, A, Donadio, ME, Chiale, F, Boido, A, Mariano, F, Mazzucco, G, Ravera, S, Cancarini, G, Magistroni, R, Beltrame, G, Rollino, C, Stratta, P, Quaglia, M, Bergia, R, Cravero, R, Cusinato, S, Benozzi, L, Savoldi, S & Licata, C 2014, 'Can tonsillectomy modify the innate and adaptive immunity pathways involved in IgA nephropathy?', Journal of Nephrology, vol. 28, no. 1, pp. 51-58. https://doi.org/10.1007/s40620-014-0086-8

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title = "Can tonsillectomy modify the innate and adaptive immunity pathways involved in IgA nephropathy?",

abstract = "The benefits of tonsillectomy in IgA nephropathy (IgAN) are still debated. Tonsillectomy may remove pathogen sources and reduce the mucosal associated lymphoid tissue (MALT), limiting degalactosylated IgA1 (deGal-IgA1) production, which is considered to be the initiating pathogenetic event leading to IgA glomerular deposition. In the European network VALIGA, 62/1147 IgAN patients underwent tonsillectomy (TxIgAN). In a cross-sectional study 15 of these patients were tested and compared to 45 non-tonsillectomized IgAN (no-TxIgAN) and healthy controls (HC) regarding levels of deGal-IgA1, and markers of innate immunity and oxidative stress, including toll-like receptors (TLR)2, 3, 4 and 9 mRNAs, proteasome (PS) and immunoproteasome (iPS) mRNAs in peripheral blood mononuclear cells (PBMC), and advanced oxidation protein products (AOPP). Levels of deGal-IgA1 were lower in TxIgAN than in no-TxIgAN (p = 0.015), but higher than in HC (p = 0.003). TLR mRNAs were more expressed in TxIgAN than in HC (TLR4, p = 0.021; TLR9, p = 0.027), and higher in TxIgAN than in no-TxIgAN (p ≤ 0.001 for TLR2, 4, 9). A switch from PS to iPS was detected in PBMC of TxIgAN in comparison to HC and it was higher than in no-TxIgAN [large multifunctional peptidase (LMP)2/β1, p = 0.039; LPM7/β5, p ",

keywords = "Aberrantly glycosylated IgA, IgA nephropathy, Immunoproteasomes, Innate immunity, Oxidative stress, Toll-like receptors, Tonsillectomy",

author = "Luca Vergano and Elisa Loiacono and Roberto Albera and Rosanna Coppo and Roberta Camilla and Licia Peruzzi and Alessandro Amore and Donadio, {Maria Elena} and Federica Chiale and Alberto Boido and Filippo Mariano and Gianna Mazzucco and Sara Ravera and Giovanni Cancarini and Riccardo Magistroni and Giulietta Beltrame and Cristiana Rollino and Piero Stratta and Marco Quaglia and Roberto Bergia and Raffaella Cravero and Stefano Cusinato and Luisa Benozzi and Silvana Savoldi and Carola Licata",

year = "2014",

doi = "10.1007/s40620-014-0086-8",

language = "English",

volume = "28",

pages = "51--58",

journal = "Journal of Nephrology",

issn = "1121-8428",