TY - JOUR
T1 - Can tonsillectomy modify the innate and adaptive immunity pathways involved in IgA nephropathy?
AU - Vergano, Luca
AU - Loiacono, Elisa
AU - Albera, Roberto
AU - Coppo, Rosanna
AU - Camilla, Roberta
AU - Peruzzi, Licia
AU - Amore, Alessandro
AU - Donadio, Maria Elena
AU - Chiale, Federica
AU - Boido, Alberto
AU - Mariano, Filippo
AU - Mazzucco, Gianna
AU - Ravera, Sara
AU - Cancarini, Giovanni
AU - Magistroni, Riccardo
AU - Beltrame, Giulietta
AU - Rollino, Cristiana
AU - Stratta, Piero
AU - Quaglia, Marco
AU - Bergia, Roberto
AU - Cravero, Raffaella
AU - Cusinato, Stefano
AU - Benozzi, Luisa
AU - Savoldi, Silvana
AU - Licata, Carola
PY - 2014
Y1 - 2014
N2 - The benefits of tonsillectomy in IgA nephropathy (IgAN) are still debated. Tonsillectomy may remove pathogen sources and reduce the mucosal associated lymphoid tissue (MALT), limiting degalactosylated IgA1 (deGal-IgA1) production, which is considered to be the initiating pathogenetic event leading to IgA glomerular deposition. In the European network VALIGA, 62/1147 IgAN patients underwent tonsillectomy (TxIgAN). In a cross-sectional study 15 of these patients were tested and compared to 45 non-tonsillectomized IgAN (no-TxIgAN) and healthy controls (HC) regarding levels of deGal-IgA1, and markers of innate immunity and oxidative stress, including toll-like receptors (TLR)2, 3, 4 and 9 mRNAs, proteasome (PS) and immunoproteasome (iPS) mRNAs in peripheral blood mononuclear cells (PBMC), and advanced oxidation protein products (AOPP). Levels of deGal-IgA1 were lower in TxIgAN than in no-TxIgAN (p = 0.015), but higher than in HC (p = 0.003). TLR mRNAs were more expressed in TxIgAN than in HC (TLR4, p = 0.021; TLR9, p = 0.027), and higher in TxIgAN than in no-TxIgAN (p ≤ 0.001 for TLR2, 4, 9). A switch from PS to iPS was detected in PBMC of TxIgAN in comparison to HC and it was higher than in no-TxIgAN [large multifunctional peptidase (LMP)2/β1, p = 0.039; LPM7/β5, p
AB - The benefits of tonsillectomy in IgA nephropathy (IgAN) are still debated. Tonsillectomy may remove pathogen sources and reduce the mucosal associated lymphoid tissue (MALT), limiting degalactosylated IgA1 (deGal-IgA1) production, which is considered to be the initiating pathogenetic event leading to IgA glomerular deposition. In the European network VALIGA, 62/1147 IgAN patients underwent tonsillectomy (TxIgAN). In a cross-sectional study 15 of these patients were tested and compared to 45 non-tonsillectomized IgAN (no-TxIgAN) and healthy controls (HC) regarding levels of deGal-IgA1, and markers of innate immunity and oxidative stress, including toll-like receptors (TLR)2, 3, 4 and 9 mRNAs, proteasome (PS) and immunoproteasome (iPS) mRNAs in peripheral blood mononuclear cells (PBMC), and advanced oxidation protein products (AOPP). Levels of deGal-IgA1 were lower in TxIgAN than in no-TxIgAN (p = 0.015), but higher than in HC (p = 0.003). TLR mRNAs were more expressed in TxIgAN than in HC (TLR4, p = 0.021; TLR9, p = 0.027), and higher in TxIgAN than in no-TxIgAN (p ≤ 0.001 for TLR2, 4, 9). A switch from PS to iPS was detected in PBMC of TxIgAN in comparison to HC and it was higher than in no-TxIgAN [large multifunctional peptidase (LMP)2/β1, p = 0.039; LPM7/β5, p
KW - Aberrantly glycosylated IgA
KW - IgA nephropathy
KW - Immunoproteasomes
KW - Innate immunity
KW - Oxidative stress
KW - Toll-like receptors
KW - Tonsillectomy
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U2 - 10.1007/s40620-014-0086-8
DO - 10.1007/s40620-014-0086-8
M3 - Article
C2 - 24756968
AN - SCOPUS:84922573023
VL - 28
SP - 51
EP - 58
JO - Journal of Nephrology
JF - Journal of Nephrology
SN - 1121-8428
IS - 1
ER -