Can tonsillectomy modify the innate and adaptive immunity pathways involved in IgA nephropathy?

Luca Vergano, Elisa Loiacono, Roberto Albera, Rosanna Coppo, Roberta Camilla, Licia Peruzzi, Alessandro Amore, Maria Elena Donadio, Federica Chiale, Alberto Boido, Filippo Mariano, Gianna Mazzucco, Sara Ravera, Giovanni Cancarini, Riccardo Magistroni, Giulietta Beltrame, Cristiana Rollino, Piero Stratta, Marco Quaglia, Roberto BergiaRaffaella Cravero, Stefano Cusinato, Luisa Benozzi, Silvana Savoldi, Carola Licata

Research output: Contribution to journalArticlepeer-review


The benefits of tonsillectomy in IgA nephropathy (IgAN) are still debated. Tonsillectomy may remove pathogen sources and reduce the mucosal associated lymphoid tissue (MALT), limiting degalactosylated IgA1 (deGal-IgA1) production, which is considered to be the initiating pathogenetic event leading to IgA glomerular deposition. In the European network VALIGA, 62/1147 IgAN patients underwent tonsillectomy (TxIgAN). In a cross-sectional study 15 of these patients were tested and compared to 45 non-tonsillectomized IgAN (no-TxIgAN) and healthy controls (HC) regarding levels of deGal-IgA1, and markers of innate immunity and oxidative stress, including toll-like receptors (TLR)2, 3, 4 and 9 mRNAs, proteasome (PS) and immunoproteasome (iPS) mRNAs in peripheral blood mononuclear cells (PBMC), and advanced oxidation protein products (AOPP). Levels of deGal-IgA1 were lower in TxIgAN than in no-TxIgAN (p = 0.015), but higher than in HC (p = 0.003). TLR mRNAs were more expressed in TxIgAN than in HC (TLR4, p = 0.021; TLR9, p = 0.027), and higher in TxIgAN than in no-TxIgAN (p ≤ 0.001 for TLR2, 4, 9). A switch from PS to iPS was detected in PBMC of TxIgAN in comparison to HC and it was higher than in no-TxIgAN [large multifunctional peptidase (LMP)2/β1, p = 0.039; LPM7/β5, p 

Original languageEnglish
Pages (from-to)51-58
Number of pages8
JournalJournal of Nephrology
Issue number1
Publication statusPublished - 2014


  • Aberrantly glycosylated IgA
  • IgA nephropathy
  • Immunoproteasomes
  • Innate immunity
  • Oxidative stress
  • Toll-like receptors
  • Tonsillectomy

ASJC Scopus subject areas

  • Nephrology


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