Can we predict tuberculosis cure? What tools are available?

D Goletti, CS Lindestam Arlehamn, TJ Scriba, R Anthony, DM Cirillo, T Alonzi, CM Denkinger, F Cobelens

Research output: Contribution to journalArticle

Abstract

Antibiotic treatment of tuberculosis takes ≥6 months, putting a major burden on patients and health systems in large parts of the world. Treatment beyond 2 months is needed to prevent tuberculosis relapse by clearing remaining, drug-tolerant Mycobacterium tuberculosis bacilli. However, the majority of patients treated for only 2-3 months will cure without relapse and do not need prolonged treatment. Assays that can identify these patients at an early stage of treatment may significantly help reduce the treatment burden, while a test to identify those patients who will fail treatment may help target host-directed therapies.In this review we summarise the state of the art with regard to discovery of biomarkers that predict relapse-free cure for pulmonary tuberculosis. Positron emission tomography/computed tomography scanning to measure pulmonary inflammation enhances our understanding of "cure". Several microbiological and immunological markers seem promising; however, they still need a formal validation. In parallel, new research strategies are needed to generate reliable tests. Copyright ©ERS 2018.
Original languageEnglish
Article number1801089
JournalEuropean Respiratory Journal
Volume52
Issue number5
DOIs
Publication statusPublished - 2018

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  • Cite this

    Goletti, D., Lindestam Arlehamn, CS., Scriba, TJ., Anthony, R., Cirillo, DM., Alonzi, T., Denkinger, CM., & Cobelens, F. (2018). Can we predict tuberculosis cure? What tools are available? European Respiratory Journal, 52(5), [1801089]. https://doi.org/10.1183/13993003.01089-2018