Can we withdraw immunosuppressants in patients with lupus nephritis in remission? An expert debate

Gabriella Moroni, Mariele Gatto, Francesca Raffiotta, Valentina Binda, Eleni Frangou, Liz Lightstone, Dimitrios T. Boumpas

Research output: Contribution to journalReview article

Abstract

Lupus nephritis (LN) treatment requires an initial intensive period of therapy followed by a long-term maintenance treatment in order to stabilize disease control and eventually reach renal remission. In this section, Authors discuss the feasibility of safely lowering and even suspending maintenance therapy in LN patients having entered remission, highlighting hurdles in predicting the depth and durability of disease quiescence together with the need for minimizing potentially toxic therapies. Even though no firm conclusions can still be drawn, the treating physician has to find the wise balance between disease control and treatment-related drawbacks by following patients closely and recognizing as early as possible the ones who are likely to reach a deep and durable renal remission; there is consensus that is these are the only patients in whom a potential safe complete withdrawal can be foreseen so far.

Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalAutoimmunity Reviews
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Immunosuppression
  • Lupus nephritis
  • Organ damage
  • Remission

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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