Abstract
Diabetes mellitus (DM) is associated with an elevated risk of cancer. The aim of this study was to assess cancer risk and survival in individuals with type 2 DM (T2DM) in Friuli Venezia Giulia, Italy. A retrospective population-based cohort study of 32,247 T2DM patients aged 40-84 years was conducted through a record linkage of local healthcare databases and cancer registry for the period 2002-2009. Standardized incidence ratios (SIRs) with 95% confidence intervals (95%CIs) and 5-year survival probabilities after T2DM and cancer diagnosis were computed. The SIRs for all cancers (n = 2069) was 1.28 (95%CI: 1.23-1.34). The highest SIRs were observed for cancers of the liver, female genital organs, small intestine, and pancreas. After 3 years from T2DM diagnosis, a reduced risk of prostate cancer (SIR = 0.73, 95%CI: 0.54-0.96) was found in men aged 65-74 years, and a higher risk for breast cancer (SIR = 1.24, 95%CI: 1.00-1.52) was found among T2DM female patients. The overall 5-year survival after T2DM was 88.7%. Furthermore, T2DM appeared to have a negative effect on survival of women with breast cancer. This population-based study confirmed that T2DM patients are at increased risk of several cancers, and of premature death in women with breast cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 80-87 |
| Number of pages | 8 |
| Journal | Cancer Epidemiology |
| Volume | 41 |
| DOIs | |
| Publication status | Published - Apr 1 2016 |
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Keywords
- Cancer
- Cancer risk
- Population-based cohort study
- Record linkage
- Survival
- Type 2 diabetes mellitus
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Epidemiology
Cite this
Cancer among patients with type 2 diabetes mellitus : A population-based cohort study in northeastern Italy. / Gini, Andrea; Bidoli, Ettore; Zanier, Loris; Clagnan, Elena; Zanette, Giorgio; Gobbato, Michele; De Paoli, Paolo; Serraino, Diego.
In: Cancer Epidemiology, Vol. 41, 01.04.2016, p. 80-87.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cancer among patients with type 2 diabetes mellitus
T2 - A population-based cohort study in northeastern Italy
AU - Gini, Andrea
AU - Bidoli, Ettore
AU - Zanier, Loris
AU - Clagnan, Elena
AU - Zanette, Giorgio
AU - Gobbato, Michele
AU - De Paoli, Paolo
AU - Serraino, Diego
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Diabetes mellitus (DM) is associated with an elevated risk of cancer. The aim of this study was to assess cancer risk and survival in individuals with type 2 DM (T2DM) in Friuli Venezia Giulia, Italy. A retrospective population-based cohort study of 32,247 T2DM patients aged 40-84 years was conducted through a record linkage of local healthcare databases and cancer registry for the period 2002-2009. Standardized incidence ratios (SIRs) with 95% confidence intervals (95%CIs) and 5-year survival probabilities after T2DM and cancer diagnosis were computed. The SIRs for all cancers (n = 2069) was 1.28 (95%CI: 1.23-1.34). The highest SIRs were observed for cancers of the liver, female genital organs, small intestine, and pancreas. After 3 years from T2DM diagnosis, a reduced risk of prostate cancer (SIR = 0.73, 95%CI: 0.54-0.96) was found in men aged 65-74 years, and a higher risk for breast cancer (SIR = 1.24, 95%CI: 1.00-1.52) was found among T2DM female patients. The overall 5-year survival after T2DM was 88.7%. Furthermore, T2DM appeared to have a negative effect on survival of women with breast cancer. This population-based study confirmed that T2DM patients are at increased risk of several cancers, and of premature death in women with breast cancer.
AB - Diabetes mellitus (DM) is associated with an elevated risk of cancer. The aim of this study was to assess cancer risk and survival in individuals with type 2 DM (T2DM) in Friuli Venezia Giulia, Italy. A retrospective population-based cohort study of 32,247 T2DM patients aged 40-84 years was conducted through a record linkage of local healthcare databases and cancer registry for the period 2002-2009. Standardized incidence ratios (SIRs) with 95% confidence intervals (95%CIs) and 5-year survival probabilities after T2DM and cancer diagnosis were computed. The SIRs for all cancers (n = 2069) was 1.28 (95%CI: 1.23-1.34). The highest SIRs were observed for cancers of the liver, female genital organs, small intestine, and pancreas. After 3 years from T2DM diagnosis, a reduced risk of prostate cancer (SIR = 0.73, 95%CI: 0.54-0.96) was found in men aged 65-74 years, and a higher risk for breast cancer (SIR = 1.24, 95%CI: 1.00-1.52) was found among T2DM female patients. The overall 5-year survival after T2DM was 88.7%. Furthermore, T2DM appeared to have a negative effect on survival of women with breast cancer. This population-based study confirmed that T2DM patients are at increased risk of several cancers, and of premature death in women with breast cancer.
KW - Cancer
KW - Cancer risk
KW - Population-based cohort study
KW - Record linkage
KW - Survival
KW - Type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=84960848779&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960848779&partnerID=8YFLogxK
U2 - 10.1016/j.canep.2016.01.011
DO - 10.1016/j.canep.2016.01.011
M3 - Article
AN - SCOPUS:84960848779
VL - 41
SP - 80
EP - 87
JO - Cancer Epidemiology
JF - Cancer Epidemiology
SN - 1877-7821
ER -