Cancer and blood coagulation

Research output: Contribution to journalArticlepeer-review

Abstract

In human patients, blood coagulation disorders often associate with cancer, even in its early stages. Recently, in vitro and in vivo experimental models have shown that oncogene expression, or inactivation of tumour suppressor genes, upregulate genes that control blood coagulation. These studies suggest that activation of blood clotting, leading to peritumoral fibrin deposition, is instrumental in cancer development. Fibrin can indeed build up a provisional matrix, supporting the invasive growth of neoplastic tissues and blood vessels. Interference with blood coagulation can thus be considered as part of a multifaceted therapeutic approach to cancer.

Original languageEnglish
Pages (from-to)1024-1027
Number of pages4
JournalCellular and Molecular Life Sciences
Volume63
Issue number9
DOIs
Publication statusPublished - May 2006

Keywords

  • Blood coagulation
  • Cancer
  • COX-2
  • Fibrin
  • Haemostasis
  • Invasive growth
  • MET
  • Oncogene
  • PAI-1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

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