Cancer and chemokines

Nicoletta Caronni, Benedetta Savino, Camilla Recordati, Alessandro Villa, Massimo Locati, Raffaella Bonecchi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Chemokines are a large family of secreted cytokines whose main function is to mediate leukocyte directional migration. Most cancers contain chemokines and express chemokine receptors as a consequence of the activity of deregulated transcription factors or tumor-suppressor genes. Indeed chemokines expression at the tumor site dictates leukocyte infiltration and angiogenesis, while chemokine receptors expression by tumor cells promotes their growth and matastatization. Chemokines also have several indirect effects on tumor growth and are a relevant element in the cancer-related infl ammation. In this chapter we will describe technical approaches available to study the role of chemokines in leukocyte infiltration and tumor metastatization in murine tumor models.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages87-96
Number of pages10
Volume1393
DOIs
Publication statusPublished - Apr 1 2016

Publication series

NameMethods in Molecular Biology
Volume1393
ISSN (Print)10643745

Keywords

  • Cancer-related infl ammation
  • Chemokines
  • Metastasis
  • Tumor-infiltrating leukocytes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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