Cancer and non-cancer controls in studies on the effect of tobacco and alcohol consumption

S. Barra, A. E. Baron, S. Franceschi, R. Talamini, C. La Vecchia

Research output: Contribution to journalArticlepeer-review


A comparison of risk estimates using controls with other cancers versus controls with acute diseases unrelated to tobacco and alcohol consumption in the study of the effect of these two factors has been performed using data on tumours of the oral cavity and pharynx from an ongoing case-control surveillance programme in Northeastern Italy. Similar results were obtained using either type of controls: as compared to never smokers, moderate smokers (≤14 cigarettes/day) showed age- and sex-adjusted odds ratio (OR) = 5.2 (95% confidence interval (CI): 2.9-9.2) when using cancer controls and 5.8 (95% CI: 3.3-10.1) when using non-cancer controls. Similarly, those who had smoked for 40 years or longer showed ORs of 7.4 (95% CI: 4.0-13.6) and 8.8 (95% CI: 4.9-15.6), respectively, using cancer and non-cancer controls. For moderate drinkers of alcoholic beverages (21-34 drinks/week) and heavy drinkers (≥84 drinks/ week) the ORs, as compared to individuals who drank

Original languageEnglish
Pages (from-to)845-851
Number of pages7
JournalInternational Journal of Epidemiology
Issue number4
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Epidemiology


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