Cancer arising after pancreas and/or kidney transplantation in a series of 99 diabetic patients

Sabina Martinenghi, Giacomo Dell'Antonio, Antonio Secchi, Valerio Di Carlo, Guido Pozza

Research output: Contribution to journalArticle

Abstract

OBJECTIVE - Recipients of solid organ transplants have an increased risk of developing certain types of malignancies as compared with the general population. The majority of the literature has reported on neoplasms in kidney and heart transplant recipients. RESEARCH DESIGN AND METHODS - We describe 9 neoplasms occurring in 7 out of 73 IDDM patients after simultaneous pancreas and kidney transplantation. No cases were recorded among 26 IDDM recipients of kidney transplantation. RESULTS - Among the neoplasms found were 2 cases of posttransplant lymphoproliferative disorder (PTLD), malignant melanoma, basal-cell and squamous-cell carcinoma of the skin in the same patient squamous-cell carcinoma in situ of the vulva, hepatocarcinoma, small-cell lung cancer, and ductal carcinoma of the breast. Four patients died. Among immunological risk factors, over-immunosuppression for steroid-resistant kidney rejection was administered only in the 2 cases of PTLD. CONCLUSIONS - Increased dosage of immunosuppressive agents may be necessary in some patients to prevent or treat rejection in view of their reduced survival on hemodialysis.

Original languageEnglish
Pages (from-to)272-275
Number of pages4
JournalDiabetes Care
Volume20
Issue number3
Publication statusPublished - Mar 1997

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Pancreas Transplantation
Kidney Transplantation
Lymphoproliferative Disorders
Small Cell Lung Carcinoma
Type 1 Diabetes Mellitus
Squamous Cell Carcinoma
Neoplasms
Ductal Carcinoma
Heart Neoplasms
Vulva
Kidney Neoplasms
Carcinoma in Situ
Immunologic Factors
Immunosuppressive Agents
Immunosuppression
Renal Dialysis
Melanoma
Breast
Research Design
Steroids

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Martinenghi, S., Dell'Antonio, G., Secchi, A., Di Carlo, V., & Pozza, G. (1997). Cancer arising after pancreas and/or kidney transplantation in a series of 99 diabetic patients. Diabetes Care, 20(3), 272-275.

Cancer arising after pancreas and/or kidney transplantation in a series of 99 diabetic patients. / Martinenghi, Sabina; Dell'Antonio, Giacomo; Secchi, Antonio; Di Carlo, Valerio; Pozza, Guido.

In: Diabetes Care, Vol. 20, No. 3, 03.1997, p. 272-275.

Research output: Contribution to journalArticle

Martinenghi, S, Dell'Antonio, G, Secchi, A, Di Carlo, V & Pozza, G 1997, 'Cancer arising after pancreas and/or kidney transplantation in a series of 99 diabetic patients', Diabetes Care, vol. 20, no. 3, pp. 272-275.
Martinenghi S, Dell'Antonio G, Secchi A, Di Carlo V, Pozza G. Cancer arising after pancreas and/or kidney transplantation in a series of 99 diabetic patients. Diabetes Care. 1997 Mar;20(3):272-275.
Martinenghi, Sabina ; Dell'Antonio, Giacomo ; Secchi, Antonio ; Di Carlo, Valerio ; Pozza, Guido. / Cancer arising after pancreas and/or kidney transplantation in a series of 99 diabetic patients. In: Diabetes Care. 1997 ; Vol. 20, No. 3. pp. 272-275.
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