Cancer as a changed tissue's way of life (when to treat, when to watch and when to think)

Romano Demicheli, Dinah Faith T Quiton, Marco Fornili, William Jm Hrushesky

Research output: Contribution to journalArticle

Abstract

The profound scientific and commercial success of molecular biology, the progress of 'cancer gene' investigation technologies, together, pushed forward the postulate that genes explain 'everything'. Yet, during the last few years the microenvironments of solid tumors have emerged as key modulators of initiation, progression and metastasis and as essential to the therapeutic response. In the present review, we provide a synthetic examination of the main traits of cells embedded into the cancer stroma and emphasize several evidences that all components of the tumor tissue cooperate in space and time. Then we turn to discuss the epitheliocentric somatic mutational view and other new paradigms assuming that disturbed tissue interactions among cell populations are critical to cancer causation, growth and spread.

Original languageEnglish
Pages (from-to)647-57
Number of pages11
JournalFuture Oncology
Volume12
Issue number5
DOIs
Publication statusPublished - Mar 2016
Externally publishedYes

Fingerprint

Neoplasms
Tumor Microenvironment
Neoplasm Genes
Cell Communication
Causality
Molecular Biology
Neoplasm Metastasis
Technology
Growth
Population
Genes
Therapeutics

Keywords

  • Animals
  • Endothelial Cells
  • Fibroblasts
  • Humans
  • Macrophages
  • Neoplasms
  • Neutrophils
  • Time Factors
  • Tumor Microenvironment
  • Journal Article
  • Review

Cite this

Demicheli, R., Quiton, D. F. T., Fornili, M., & Hrushesky, W. J. (2016). Cancer as a changed tissue's way of life (when to treat, when to watch and when to think). Future Oncology, 12(5), 647-57. https://doi.org/10.2217/fon.15.336

Cancer as a changed tissue's way of life (when to treat, when to watch and when to think). / Demicheli, Romano; Quiton, Dinah Faith T; Fornili, Marco; Hrushesky, William Jm.

In: Future Oncology, Vol. 12, No. 5, 03.2016, p. 647-57.

Research output: Contribution to journalArticle

Demicheli, R, Quiton, DFT, Fornili, M & Hrushesky, WJ 2016, 'Cancer as a changed tissue's way of life (when to treat, when to watch and when to think)', Future Oncology, vol. 12, no. 5, pp. 647-57. https://doi.org/10.2217/fon.15.336
Demicheli, Romano ; Quiton, Dinah Faith T ; Fornili, Marco ; Hrushesky, William Jm. / Cancer as a changed tissue's way of life (when to treat, when to watch and when to think). In: Future Oncology. 2016 ; Vol. 12, No. 5. pp. 647-57.
@article{bdf6b9a9f03b4c42b3f6bd72c58dd4e5,
title = "Cancer as a changed tissue's way of life (when to treat, when to watch and when to think)",
abstract = "The profound scientific and commercial success of molecular biology, the progress of 'cancer gene' investigation technologies, together, pushed forward the postulate that genes explain 'everything'. Yet, during the last few years the microenvironments of solid tumors have emerged as key modulators of initiation, progression and metastasis and as essential to the therapeutic response. In the present review, we provide a synthetic examination of the main traits of cells embedded into the cancer stroma and emphasize several evidences that all components of the tumor tissue cooperate in space and time. Then we turn to discuss the epitheliocentric somatic mutational view and other new paradigms assuming that disturbed tissue interactions among cell populations are critical to cancer causation, growth and spread.",
keywords = "Animals, Endothelial Cells, Fibroblasts, Humans, Macrophages, Neoplasms, Neutrophils, Time Factors, Tumor Microenvironment, Journal Article, Review",
author = "Romano Demicheli and Quiton, {Dinah Faith T} and Marco Fornili and Hrushesky, {William Jm}",
year = "2016",
month = "3",
doi = "10.2217/fon.15.336",
language = "English",
volume = "12",
pages = "647--57",
journal = "Future Oncology",
issn = "1479-6694",
publisher = "Future Medicine Ltd.",
number = "5",

}

TY - JOUR

T1 - Cancer as a changed tissue's way of life (when to treat, when to watch and when to think)

AU - Demicheli, Romano

AU - Quiton, Dinah Faith T

AU - Fornili, Marco

AU - Hrushesky, William Jm

PY - 2016/3

Y1 - 2016/3

N2 - The profound scientific and commercial success of molecular biology, the progress of 'cancer gene' investigation technologies, together, pushed forward the postulate that genes explain 'everything'. Yet, during the last few years the microenvironments of solid tumors have emerged as key modulators of initiation, progression and metastasis and as essential to the therapeutic response. In the present review, we provide a synthetic examination of the main traits of cells embedded into the cancer stroma and emphasize several evidences that all components of the tumor tissue cooperate in space and time. Then we turn to discuss the epitheliocentric somatic mutational view and other new paradigms assuming that disturbed tissue interactions among cell populations are critical to cancer causation, growth and spread.

AB - The profound scientific and commercial success of molecular biology, the progress of 'cancer gene' investigation technologies, together, pushed forward the postulate that genes explain 'everything'. Yet, during the last few years the microenvironments of solid tumors have emerged as key modulators of initiation, progression and metastasis and as essential to the therapeutic response. In the present review, we provide a synthetic examination of the main traits of cells embedded into the cancer stroma and emphasize several evidences that all components of the tumor tissue cooperate in space and time. Then we turn to discuss the epitheliocentric somatic mutational view and other new paradigms assuming that disturbed tissue interactions among cell populations are critical to cancer causation, growth and spread.

KW - Animals

KW - Endothelial Cells

KW - Fibroblasts

KW - Humans

KW - Macrophages

KW - Neoplasms

KW - Neutrophils

KW - Time Factors

KW - Tumor Microenvironment

KW - Journal Article

KW - Review

U2 - 10.2217/fon.15.336

DO - 10.2217/fon.15.336

M3 - Article

VL - 12

SP - 647

EP - 657

JO - Future Oncology

JF - Future Oncology

SN - 1479-6694

IS - 5

ER -