Cancer as quasi-attractor in the gene expression phase space

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

It takes no more than 250 tissue types to build up a metazoan, and each tissue has a specific and largely invariant gene expression signature. This implies the 'viable configurations' correspondent to a given activated/inactivated expression pattern over the entire genome are very few. This points to the presence of few 'low energy deep valleys' correspondent to the allowed states of the system and is a direct consequence of the fact genes do not work by alone but embedded into genetic expression networks. Statistical thermodynamics formalism focusing on the changes in the degree of correlation of the studied systems allows to detect transition behavior in gene expression phase space resembling the phase transition of physical-chemistry studies. In this realm cancer can be intended as a sort of 'parasite' sub-attractor of the corresponding healthy tissue that, in the case of disease, is 'kinetically entrapped' into a sub-optimal solution. The consequences of such a state of affair for cancer therapies are potentially huge.

Original languageEnglish
Title of host publicationPhysics of Cancer
Subtitle of host publicationInterdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017
PublisherAmerican Institute of Physics Inc.
Volume1882
ISBN (Electronic)9780735415621
DOIs
Publication statusPublished - Sep 28 2017
EventInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 - Tomsk, Russian Federation
Duration: May 23 2017May 26 2017

Conference

ConferenceInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017
CountryRussian Federation
CityTomsk
Period5/23/175/26/17

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Fingerprint Dive into the research topics of 'Cancer as quasi-attractor in the gene expression phase space'. Together they form a unique fingerprint.

Cite this