Cancer associated fibroblasts in hematological malignancies

Lizzia Raffaghello, Angelo Vacca, Vito Pistoia, Domenico Ribatti

Research output: Contribution to journalArticle

Abstract

Tumor microenvironment plays an important role in cancer initiation and progression. In hematological malignancies, the bone marrow represents the paradigmatic anatomical site in which tumor microenvironment expresses its morphofunctional features. Among the cells participating in the composition of this microenvironment, cancer associated fibrobasts (CAFs) have received less attention in hematopoietic tumors compared to solid cancers. In this review article, we discuss the involvement of CAFs in progression of hematological malignancies and the potential targeting of CAFs in a therapeutic perspective.

Original languageEnglish
Pages (from-to)2589-2603
Number of pages15
JournalOncotarget
Volume6
Issue number5
Publication statusPublished - 2015

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Keywords

  • Cancer associated fibroblasts
  • Hematological malignancies
  • Mesenchymal stromal cells
  • Tumor microenvironment

ASJC Scopus subject areas

  • Oncology

Cite this

Raffaghello, L., Vacca, A., Pistoia, V., & Ribatti, D. (2015). Cancer associated fibroblasts in hematological malignancies. Oncotarget, 6(5), 2589-2603.