Cancer detection with TRUS-guided 10-core biopsy of the prostate. An institutional assessment at the first, repeated and surgical specimen biopsy

Fabio Campodonico, Antonio Casarico, Lorenzo Gavazzi, Tiziana Calcagno, Giacomo Capponi, Giorgio Canepa, Roberto Bandelloni, Massimo Maffezzini

Research output: Contribution to journalArticle

Abstract

Objectives: We retrospectively investigated the results of the 10-core scheme that our institute has adopted for three years. The aim of this study is to evaluate the cancer detection rate in different sets of biopsies (first, second, third and surgical specimen biopsy). Material and Methods: Patients with clinical suspicion of prostate cancer based on abnormal digital rectal examination, increase of PSA or hypoechoic lesion at transrectal ultrasound were subjected to a 10-core biopsy. Ten biopsies were taken following the traditional sextant technique and 4 more biopsies were obtained from the lateral peripheral zone. In addition, a group of 19 specimens of retropubic radical prostatectomy were biopsied immediately following surgery. Results: Of 664 patients 247 (37.2%) were positive for prostate cancer at first biopsy. Eighty-one out of 664 patients were subjected to a second biopsy for persistent elevation or increasing of PSA, or in case of tumor associated histological findings such as high PIN and ASAP. The cancer detection rate in this group was 19.8% (16/81). Of the remaining 65 patients who were negative at second biopsy, 12 received a third biopsy for persistent clinical suspect of cancer, and 2 were positive (16.7%). In 19 surgical specimens, 14 biopsies were confirmed positive and 5 were negative (73.7%). Conclusions: The extended biopsy such as the 10-core scheme showed to be a reliable protocol, taking an adequate cancer detection rate either at first or repeated biopsy with no increase in morbidity.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalArchivio Italiano di Urologia e Andrologia
Volume78
Issue number2
Publication statusPublished - Jun 2006

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Keywords

  • Extended biopsy
  • Prostate cancer
  • Repeated biopsy
  • Surgical specimen biopsy

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Campodonico, F., Casarico, A., Gavazzi, L., Calcagno, T., Capponi, G., Canepa, G., Bandelloni, R., & Maffezzini, M. (2006). Cancer detection with TRUS-guided 10-core biopsy of the prostate. An institutional assessment at the first, repeated and surgical specimen biopsy. Archivio Italiano di Urologia e Andrologia, 78(2), 39-43.