TY - JOUR
T1 - Cancer extracellular vesicles
T2 - Next-generation diagnostic and drug delivery nanotools
AU - Palazzolo, Stefano
AU - Memeo, Lorenzo
AU - Hadla, Mohamad
AU - Duzagac, Fahriye
AU - Steffan, Agostino
AU - Perin, Tiziana
AU - Canzonieri, Vincenzo
AU - Tuccinardi, Tiziano
AU - Caligiuri, Isabella
AU - Rizzolio, Flavio
N1 - Funding Information:
Funding: This work was financially supported by Fondazione AIRC per la Ricerca sul Cancro (Grant AIRC IG23566) and Ministero della Salute—Ricerca Corrente.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11
Y1 - 2020/11
N2 - Nanosized extracellular vesicles (EVs) with dimensions ranging from 100 to 1000 nm are continuously secreted from different cells in their extracellular environment. They are able to encapsulate and transfer various biomolecules, such as nucleic acids, proteins, and lipids, that play an essential role in cell-cell communication, reflecting a novel method of extracellular cross-talk. Since EVs are present in large amounts in most bodily fluids, challengeable hypotheses are analyzed to unlock their potential roles. Here, we review EVs by discussing their specific characteristics (structure, formation, composition, and isolation methods), focusing on their key role in cell biology. Furthermore, this review will summarize the biomedical applications of EVs, in particular those between 30 and 150 nm (like exosomes), as next-generation diagnostic tools in liquid biopsy for cancer and as novel drug delivery vehicles.
AB - Nanosized extracellular vesicles (EVs) with dimensions ranging from 100 to 1000 nm are continuously secreted from different cells in their extracellular environment. They are able to encapsulate and transfer various biomolecules, such as nucleic acids, proteins, and lipids, that play an essential role in cell-cell communication, reflecting a novel method of extracellular cross-talk. Since EVs are present in large amounts in most bodily fluids, challengeable hypotheses are analyzed to unlock their potential roles. Here, we review EVs by discussing their specific characteristics (structure, formation, composition, and isolation methods), focusing on their key role in cell biology. Furthermore, this review will summarize the biomedical applications of EVs, in particular those between 30 and 150 nm (like exosomes), as next-generation diagnostic tools in liquid biopsy for cancer and as novel drug delivery vehicles.
KW - Cancer
KW - Diagnostics
KW - Drug delivery
KW - Extracellular vesicles
KW - Microvesicles
KW - Nanomedicine
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U2 - 10.3390/cancers12113165
DO - 10.3390/cancers12113165
M3 - Article
AN - SCOPUS:85094591469
VL - 12
SP - 1
EP - 36
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 11
M1 - 3165
ER -