Cancer in a young population in a dioxin-contaminated area

A. C. Pesatori, D. Consonni, A. Tironi, C. Zocchetti, A. Fini, P. A. Bertazzi

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Abstract

An industrial accident in Seveso, Italy, in 1976, caused contamination of the residential community with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). We investigated cancer occurrence in the first post-accident decade (1977-1986) among nearly 20 000 subjects aged 0-19 years. People who left the area were actively followed with a 99% follow-up rate. For reported cancer cases confirmation was obtained through consultation with original medical records. Two ovarian cancers were observed versus none expected. A suggestive increase was seen for Hodgkin's lymphoma (relative risk [RR] = 2.0; 95% confidence interval [CI] = 0.5-7.6). Myeloid leukaemia showed a clear, but not statistically significant increase (RR = 2.7; 95% CI = 0.7-11.4). The most prominent result concerned thyroid cancer, not just for the magnitude of the increase (two cases, RR = 4.6; 95% CI = 0.6-32.7), but also for its consistency with experimental findings and previous observations in humans. Any conclusive interpretation would be premature because of the short time since initial exposure, ecological definition of exposure status, and limited number of events.

Original languageEnglish
Pages (from-to)1010-1013
Number of pages4
JournalInternational Journal of Epidemiology
Volume22
Issue number6
Publication statusPublished - 1993

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Dioxins
Confidence Intervals
Population
Occupational Accidents
Neoplasms
Myeloid Leukemia
Hodgkin Disease
Thyroid Neoplasms
Ovarian Neoplasms
Italy
Accidents
Medical Records
Referral and Consultation

ASJC Scopus subject areas

  • Epidemiology

Cite this

Cancer in a young population in a dioxin-contaminated area. / Pesatori, A. C.; Consonni, D.; Tironi, A.; Zocchetti, C.; Fini, A.; Bertazzi, P. A.

In: International Journal of Epidemiology, Vol. 22, No. 6, 1993, p. 1010-1013.

Research output: Contribution to journalArticle

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