Stima dell'incidenza del carcinoma mammario attraverso il flusso dei ricoveri ospedalieri: Confronto con i dati dei registri tumori

Translated title of the contribution: Cancer incidence estimation by hospital discharge flow as compared with cancer registries data

Stefano Ferretti, Stefano Guzzinati, Paola Zambon, Gianfranco Manneschi, Emanuele Crocetti, Fabio Falcini, Stefania Giorgetti, Claudia Cirilli, Monica Pirani, Lucia Mangone, Enza Di Felice, Vincenzo Del Lisi, Paolo Sgargi, Carlotta Buzzoni, Antonio Russo, Eugenio Paci

Research output: Contribution to journalArticle

Abstract

Objective: the study evaluates the accuracy of an algorithm based on hospital discharge data (HDD) in order to estimate breast cancer incidence in three italian regions (Emilia-Romagna, Toscana and Veneto) covered by cancer registries (CR). The evolution of computer-based information systems in health organization suggests automatic processing of HDD as a possible alternative to the time-consuming methods of CR. The study intends to verify whether HDD quickly provides reliable cancer incidence estimates for diagnosis and therapy evaluations. Design and setting: an algorithm based on discharge diagnosis and surgical therapy of hospitalized breast cancer patients was developed in order to provide breast cancer incidence. Results were compared with the corresponding incidence data of cancer registries. The accuracy of the automatic method was also verified by a direct record-linkage between HDD output and registries' files. The overall survival of cases lost to "HDD method" was analyzed. Results: in the period covered by the study (3,125,425 personlyear) CR enrolled 6,079 incident cases, compared to 6,000 cases recorded through the HDD flow. Incidence rates of the two methods (CR 194.5; HDD 192.0 × 100.000) showed no statistical differences. However, matched cases by the two methods were only 5,038. The sensitivity of the HDD algorithm was 82.9% and its predictive positive value (PPV) was 84.0%. False positive cases were 9.9%. On the other hand, 12.3% CR incident cases were not identified by the algorithm: these were mainly made up of older women, not eligible for surgical therapy. Their three-years survival was 62.0% vs 88.8% of the whole incidence group. Conclusion: HDD flow performance was similar to observations reported in the literature. The agreement between HDD and CR incidence rates is a result of a cross effect of both sensitivity and specificity limitations of the HDD algorithm. This can seriously impair the reliability of the latter method with regard to the evaluation of diagnostic and therapeutic strategies in cohort studies (i.e. the most effective approach to health setting in oncology).

Original languageItalian
Pages (from-to)147-153
Number of pages7
JournalEpidemiologia e prevenzione
Volume33
Issue number4-5
Publication statusPublished - Jul 2009

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Registries
Incidence
Neoplasms
Breast Neoplasms
Health Information Systems
Survival
Therapeutics
Cohort Studies
Sensitivity and Specificity
Health

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Stima dell'incidenza del carcinoma mammario attraverso il flusso dei ricoveri ospedalieri : Confronto con i dati dei registri tumori. / Ferretti, Stefano; Guzzinati, Stefano; Zambon, Paola; Manneschi, Gianfranco; Crocetti, Emanuele; Falcini, Fabio; Giorgetti, Stefania; Cirilli, Claudia; Pirani, Monica; Mangone, Lucia; Di Felice, Enza; Del Lisi, Vincenzo; Sgargi, Paolo; Buzzoni, Carlotta; Russo, Antonio; Paci, Eugenio.

In: Epidemiologia e prevenzione, Vol. 33, No. 4-5, 07.2009, p. 147-153.

Research output: Contribution to journalArticle

Ferretti, S, Guzzinati, S, Zambon, P, Manneschi, G, Crocetti, E, Falcini, F, Giorgetti, S, Cirilli, C, Pirani, M, Mangone, L, Di Felice, E, Del Lisi, V, Sgargi, P, Buzzoni, C, Russo, A & Paci, E 2009, 'Stima dell'incidenza del carcinoma mammario attraverso il flusso dei ricoveri ospedalieri: Confronto con i dati dei registri tumori', Epidemiologia e prevenzione, vol. 33, no. 4-5, pp. 147-153.
Ferretti, Stefano ; Guzzinati, Stefano ; Zambon, Paola ; Manneschi, Gianfranco ; Crocetti, Emanuele ; Falcini, Fabio ; Giorgetti, Stefania ; Cirilli, Claudia ; Pirani, Monica ; Mangone, Lucia ; Di Felice, Enza ; Del Lisi, Vincenzo ; Sgargi, Paolo ; Buzzoni, Carlotta ; Russo, Antonio ; Paci, Eugenio. / Stima dell'incidenza del carcinoma mammario attraverso il flusso dei ricoveri ospedalieri : Confronto con i dati dei registri tumori. In: Epidemiologia e prevenzione. 2009 ; Vol. 33, No. 4-5. pp. 147-153.
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AU - Guzzinati, Stefano

AU - Zambon, Paola

AU - Manneschi, Gianfranco

AU - Crocetti, Emanuele

AU - Falcini, Fabio

AU - Giorgetti, Stefania

AU - Cirilli, Claudia

AU - Pirani, Monica

AU - Mangone, Lucia

AU - Di Felice, Enza

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