TY - JOUR
T1 - Cancer incidence in a population accidentally exposed to 2,3,7,8-tetrachlorodibenzo-para-dioxin
AU - Bertazzi, Pier Alberto
AU - Pesatori, Angela C.
AU - Consonni, Dario
AU - Tironi, Adriana
AU - Landi, Maria Teresa
AU - Zocchetti, Carlo
PY - 1993
Y1 - 1993
N2 - In 1976, an accident in a plant near Seveso, Italy, exposed the local population to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Persons residing in three zones of decreasing TCDD contamination (A, B, and R) and a reference population were followed up for cancer occurrence in 1977–1986. The most exposed subgroup (A) was small, and only 14 cancer cases were observed. In zone B, hepatobiliary cancer was elevated, especially for those living in the area for >5 years [relative risk (RR) = 2.8; 95% confidence interval (CI) = 1.2–6.3]. Men exhibited an increase in hematologic neoplasms, most notably lymphoreticulosarcoma (RR = 5.7; 95% CI = 1.7–19.0). Women experienced an increased incidence of multiple myeloma (RR = 5.3; 95% CI = 1.2–22.6) and myeloid leukemia (RR = 3.7; 95% CI = 0.9–15.7). In zone R, the incidence of soft tissue tumors and non-Hodgkin’s lymphomas was elevated, particularly among persons living in the area for >5 years (RR = 3.5; 95% CI = 1.2–10.4 for sarcomas, and RR = 2.0; 95% CI = 1.2–3.6 for non-Hodgkin’s lymphomas). Breast cancer among females was below expectations in the most contaminated zones, and a clear deficit for endometrial cancer was observed in zones B and R.
AB - In 1976, an accident in a plant near Seveso, Italy, exposed the local population to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Persons residing in three zones of decreasing TCDD contamination (A, B, and R) and a reference population were followed up for cancer occurrence in 1977–1986. The most exposed subgroup (A) was small, and only 14 cancer cases were observed. In zone B, hepatobiliary cancer was elevated, especially for those living in the area for >5 years [relative risk (RR) = 2.8; 95% confidence interval (CI) = 1.2–6.3]. Men exhibited an increase in hematologic neoplasms, most notably lymphoreticulosarcoma (RR = 5.7; 95% CI = 1.7–19.0). Women experienced an increased incidence of multiple myeloma (RR = 5.3; 95% CI = 1.2–22.6) and myeloid leukemia (RR = 3.7; 95% CI = 0.9–15.7). In zone R, the incidence of soft tissue tumors and non-Hodgkin’s lymphomas was elevated, particularly among persons living in the area for >5 years (RR = 3.5; 95% CI = 1.2–10.4 for sarcomas, and RR = 2.0; 95% CI = 1.2–3.6 for non-Hodgkin’s lymphomas). Breast cancer among females was below expectations in the most contaminated zones, and a clear deficit for endometrial cancer was observed in zones B and R.
KW - Dioxins
KW - Disasters
KW - Environmental carcinogens
KW - Environmental health
KW - Epidemiologic methods
KW - Hormone-dependent neoplasms
KW - Soft tissue neoplasms
UR - http://www.scopus.com/inward/record.url?scp=0027264457&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027264457&partnerID=8YFLogxK
M3 - Article
C2 - 8399687
AN - SCOPUS:0027264457
VL - 4
SP - 398
EP - 406
JO - Epidemiology
JF - Epidemiology
SN - 1044-3983
IS - 5
ER -