Cancer incidence in children and young adults living in industrially contaminated sites: From the Italian experience to the development of an international surveillance system

I. Iavarone, C. Buzzoni, G. Stoppa, E. Steliarova-Foucher, Rocco Galasso

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: this paper is based upon work from COST Action ICSHNet. Children's environmental health is on the 2030 Agenda for Sustainable Development. The incidence of childhood cancer is increasing worldwide and in Europe. Yet, the aetiology of most childhood cancers, including the role of environmental carcinogens, is still largely unknown. Contaminated areas, especially of industrial origin, are of high concern due to complex mix of hazardous pollutants and their potential health impacts on human populations, notably in children. OBJECTIVES: to describe cancer risk in children and young adults (YA) residing in national priority contaminated sites (NPCSs) in Italy and to provide a suitable framework for a development of cancer surveillance in industrially contaminated sites (ICSs) in Europe. METHODS: this study is based on a collaborative work of the Italian Institute of Health (ISS) and the Italian Association of Cancer Registries (AIRTUM), in the context of the SENTIERI project (Epidemiological study of residents in National Priority Contaminated Sites). Incidence rates were standardised according to the European standard population. The number of observed cases was compared to the expected cases derived from the age-, sex-, and cancer-specific incidence rates of the national pool of AIRTUM registries for the period 2006-2013. Standardized incidence ratios (SIRs) and 90% confidence intervals (CIs) were computed. The study reports the cancer profile in all combined 28 NPCSs covered by 22 cancer registries. RESULTS: 1,050 cases of malignant tumours (MTs) were recorded among 3,161,786 person-years in people aged 0-29 years in 28 NPCSs (SIR: 1.03; 90%CI 0.98-1.09), with an age-standardised incidence rate of 317 per million. Excess risks were observed for: MT of the central nervous system in the age-group
Original languageEnglish
Pages (from-to)76-85
Number of pages10
JournalEpidemiologia e prevenzione
Volume42
Issue number5-6
DOIs
Publication statusPublished - 2018

Keywords

  • adolescent
  • adult
  • child
  • clinical trial
  • environmental monitoring
  • Europe
  • female
  • human
  • incidence
  • industry
  • infant
  • international cooperation
  • Italy
  • male
  • multicenter study
  • neoplasm
  • newborn
  • pollution
  • preschool child
  • procedures
  • young adult
  • Adolescent
  • Adult
  • Child
  • Preschool
  • Environmental Monitoring
  • Environmental Pollution
  • Female
  • Humans
  • Incidence
  • Industry
  • Infant
  • Newborn
  • Internationality
  • Male
  • Neoplasms
  • Young Adult

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