Cancer incidence in Italian contaminated sites

Pietro Comba, Paolo Ricci, Ivano Iavarone, Roberta Pirastu, Carlotta Buzzoni, Mario Fusco, Stefano Ferretti, Lucia Fazzo, Roberto Pasetto, Amerigo Zona, Emanuele Crocetti, M. Autelitano, E. Beccaloni, M. Benedetti, L. Benfatto, A. Biggeri, A. Binazzi, F. Bianconi, E. Bidoli, C. BrunoC. Buzzoni, G. Candela, M. Carere, D. Catelan, M. Cocchioni, P. Comba, S. Conti, M. Corfiati, E. Coviello, L. Cremone, E. Crocetti, A. P. Dei Tos, M. De Santis, F. Falcini, F. Falleni, L. Fazzo, M. Federico, S. Ferretti, M. Fusco, A. Giacomin, G. Gola, L. Grisotto, S. Guzzinati, I. Iavarone, F. La Rosa, L. Lillini, A. Madeddu, M. Magoni, L. Mangone, V. Manno, I. Marcello, A. Marinaccio, G. Marsili, S. Maspero, M. Maule, G. Mazzoleni, F. Merletti, G. Minelli, A. Minerba, M. Michiara, C. Nicita, F. Pannozzo, R. Pasetto, A. Piccardi, S. Piffer, R. Pirastu, P. Pisani, P. Ricci, M. Santoro, F. Scaini, S. Sciacca, O. Sechi, D. Serraino, M. E. Soggiu, F. Stracci, A. Sutera Sardo, G. Tagliabue, F. Tisano, M. Usala, M. Vercelli, F. Vitale, S. Vitarelli, P. Zambon, A. Zona

Research output: Contribution to journalArticle

Abstract

Introduction: The incidence of cancer among residents in sites contaminated by pollutants with a possible health impact is not adequately studied. In Italy, SENTIERI Project (Epidemiological study of residents in National Priority Contaminated Sites, NPCSs) was implemented to study major health outcomes for residents in 44 NPCSs. Methods: The Italian Association of Cancer Registries (AIRTUM) records cancer incidence in 23 NPCSs. For each NPCSs, the incidence of all malignant cancers combined and 35 cancer sites (coded according to ICD-10), was analysed (1996-2005). The observed cases were compared to the expected based on age (5-year period, 18 classes), gender, calendar period (1996-2000; 2001-2005), geographical area (North-Centre and Centre-South) and cancer sites specific rates. Standardized Incidence Ratios (SIR) with 90% Confidence Intervals were computed. Results: In both genders an excess was observed for overall cancer incidence (9% in men and 7% in women) as well as for specific cancer sites (colon and rectum, liver, gallbladder, pancreas, lung, skin melanoma, bladder and Non Hodgkin lymphoma). Deficits were observed for gastric cancer in both genders, chronic lymphoid leukemia (men), malignant thyroid neoplasms, corpus uteri and connective and soft-tissue tumours and sarcomas (women). Discussion: This report is, to our knowledge, the first one on cancer risk of residents in NPCSs. The study, although not aiming to estimate the cancer burden attributable to the environment as compared to occupation or life-style, supports the credibility of an etiologic role of environmental exposures in contaminated sites. Ongoing analyses focus on the interpretation of risk factors for excesses of specific cancer types overall and in specific NPCSs in relation to the presence of carcinogenic pollutants.

Original languageEnglish
Pages (from-to)186-191
Number of pages6
JournalAnnali dell'Istituto Superiore di Sanita
Volume50
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Incidence
Neoplasms
Lymphoid Leukemia
Environmental Exposure
Health
International Classification of Diseases
Rectal Neoplasms
Gallbladder
Thyroid Neoplasms
Occupations
Sarcoma
Connective Tissue
Non-Hodgkin's Lymphoma
Colonic Neoplasms
Italy
Stomach Neoplasms
Uterus
Registries
Life Style
Epidemiologic Studies

Keywords

  • Cancer incidence
  • Contaminated sites
  • Environmental pollution

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Comba, P., Ricci, P., Iavarone, I., Pirastu, R., Buzzoni, C., Fusco, M., ... Zona, A. (2014). Cancer incidence in Italian contaminated sites. Annali dell'Istituto Superiore di Sanita, 50(2), 186-191. https://doi.org/10.4415/ANN-14-02-13

Cancer incidence in Italian contaminated sites. / Comba, Pietro; Ricci, Paolo; Iavarone, Ivano; Pirastu, Roberta; Buzzoni, Carlotta; Fusco, Mario; Ferretti, Stefano; Fazzo, Lucia; Pasetto, Roberto; Zona, Amerigo; Crocetti, Emanuele; Autelitano, M.; Beccaloni, E.; Benedetti, M.; Benfatto, L.; Biggeri, A.; Binazzi, A.; Bianconi, F.; Bidoli, E.; Bruno, C.; Buzzoni, C.; Candela, G.; Carere, M.; Catelan, D.; Cocchioni, M.; Comba, P.; Conti, S.; Corfiati, M.; Coviello, E.; Cremone, L.; Crocetti, E.; Dei Tos, A. P.; De Santis, M.; Falcini, F.; Falleni, F.; Fazzo, L.; Federico, M.; Ferretti, S.; Fusco, M.; Giacomin, A.; Gola, G.; Grisotto, L.; Guzzinati, S.; Iavarone, I.; La Rosa, F.; Lillini, L.; Madeddu, A.; Magoni, M.; Mangone, L.; Manno, V.; Marcello, I.; Marinaccio, A.; Marsili, G.; Maspero, S.; Maule, M.; Mazzoleni, G.; Merletti, F.; Minelli, G.; Minerba, A.; Michiara, M.; Nicita, C.; Pannozzo, F.; Pasetto, R.; Piccardi, A.; Piffer, S.; Pirastu, R.; Pisani, P.; Ricci, P.; Santoro, M.; Scaini, F.; Sciacca, S.; Sechi, O.; Serraino, D.; Soggiu, M. E.; Stracci, F.; Sardo, A. Sutera; Tagliabue, G.; Tisano, F.; Usala, M.; Vercelli, M.; Vitale, F.; Vitarelli, S.; Zambon, P.; Zona, A.

In: Annali dell'Istituto Superiore di Sanita, Vol. 50, No. 2, 2014, p. 186-191.

Research output: Contribution to journalArticle

Comba, P, Ricci, P, Iavarone, I, Pirastu, R, Buzzoni, C, Fusco, M, Ferretti, S, Fazzo, L, Pasetto, R, Zona, A, Crocetti, E, Autelitano, M, Beccaloni, E, Benedetti, M, Benfatto, L, Biggeri, A, Binazzi, A, Bianconi, F, Bidoli, E, Bruno, C, Buzzoni, C, Candela, G, Carere, M, Catelan, D, Cocchioni, M, Comba, P, Conti, S, Corfiati, M, Coviello, E, Cremone, L, Crocetti, E, Dei Tos, AP, De Santis, M, Falcini, F, Falleni, F, Fazzo, L, Federico, M, Ferretti, S, Fusco, M, Giacomin, A, Gola, G, Grisotto, L, Guzzinati, S, Iavarone, I, La Rosa, F, Lillini, L, Madeddu, A, Magoni, M, Mangone, L, Manno, V, Marcello, I, Marinaccio, A, Marsili, G, Maspero, S, Maule, M, Mazzoleni, G, Merletti, F, Minelli, G, Minerba, A, Michiara, M, Nicita, C, Pannozzo, F, Pasetto, R, Piccardi, A, Piffer, S, Pirastu, R, Pisani, P, Ricci, P, Santoro, M, Scaini, F, Sciacca, S, Sechi, O, Serraino, D, Soggiu, ME, Stracci, F, Sardo, AS, Tagliabue, G, Tisano, F, Usala, M, Vercelli, M, Vitale, F, Vitarelli, S, Zambon, P & Zona, A 2014, 'Cancer incidence in Italian contaminated sites', Annali dell'Istituto Superiore di Sanita, vol. 50, no. 2, pp. 186-191. https://doi.org/10.4415/ANN-14-02-13
Comba P, Ricci P, Iavarone I, Pirastu R, Buzzoni C, Fusco M et al. Cancer incidence in Italian contaminated sites. Annali dell'Istituto Superiore di Sanita. 2014;50(2):186-191. https://doi.org/10.4415/ANN-14-02-13
Comba, Pietro ; Ricci, Paolo ; Iavarone, Ivano ; Pirastu, Roberta ; Buzzoni, Carlotta ; Fusco, Mario ; Ferretti, Stefano ; Fazzo, Lucia ; Pasetto, Roberto ; Zona, Amerigo ; Crocetti, Emanuele ; Autelitano, M. ; Beccaloni, E. ; Benedetti, M. ; Benfatto, L. ; Biggeri, A. ; Binazzi, A. ; Bianconi, F. ; Bidoli, E. ; Bruno, C. ; Buzzoni, C. ; Candela, G. ; Carere, M. ; Catelan, D. ; Cocchioni, M. ; Comba, P. ; Conti, S. ; Corfiati, M. ; Coviello, E. ; Cremone, L. ; Crocetti, E. ; Dei Tos, A. P. ; De Santis, M. ; Falcini, F. ; Falleni, F. ; Fazzo, L. ; Federico, M. ; Ferretti, S. ; Fusco, M. ; Giacomin, A. ; Gola, G. ; Grisotto, L. ; Guzzinati, S. ; Iavarone, I. ; La Rosa, F. ; Lillini, L. ; Madeddu, A. ; Magoni, M. ; Mangone, L. ; Manno, V. ; Marcello, I. ; Marinaccio, A. ; Marsili, G. ; Maspero, S. ; Maule, M. ; Mazzoleni, G. ; Merletti, F. ; Minelli, G. ; Minerba, A. ; Michiara, M. ; Nicita, C. ; Pannozzo, F. ; Pasetto, R. ; Piccardi, A. ; Piffer, S. ; Pirastu, R. ; Pisani, P. ; Ricci, P. ; Santoro, M. ; Scaini, F. ; Sciacca, S. ; Sechi, O. ; Serraino, D. ; Soggiu, M. E. ; Stracci, F. ; Sardo, A. Sutera ; Tagliabue, G. ; Tisano, F. ; Usala, M. ; Vercelli, M. ; Vitale, F. ; Vitarelli, S. ; Zambon, P. ; Zona, A. / Cancer incidence in Italian contaminated sites. In: Annali dell'Istituto Superiore di Sanita. 2014 ; Vol. 50, No. 2. pp. 186-191.
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TY - JOUR

T1 - Cancer incidence in Italian contaminated sites

AU - Comba, Pietro

AU - Ricci, Paolo

AU - Iavarone, Ivano

AU - Pirastu, Roberta

AU - Buzzoni, Carlotta

AU - Fusco, Mario

AU - Ferretti, Stefano

AU - Fazzo, Lucia

AU - Pasetto, Roberto

AU - Zona, Amerigo

AU - Crocetti, Emanuele

AU - Autelitano, M.

AU - Beccaloni, E.

AU - Benedetti, M.

AU - Benfatto, L.

AU - Biggeri, A.

AU - Binazzi, A.

AU - Bianconi, F.

AU - Bidoli, E.

AU - Bruno, C.

AU - Buzzoni, C.

AU - Candela, G.

AU - Carere, M.

AU - Catelan, D.

AU - Cocchioni, M.

AU - Comba, P.

AU - Conti, S.

AU - Corfiati, M.

AU - Coviello, E.

AU - Cremone, L.

AU - Crocetti, E.

AU - Dei Tos, A. P.

AU - De Santis, M.

AU - Falcini, F.

AU - Falleni, F.

AU - Fazzo, L.

AU - Federico, M.

AU - Ferretti, S.

AU - Fusco, M.

AU - Giacomin, A.

AU - Gola, G.

AU - Grisotto, L.

AU - Guzzinati, S.

AU - Iavarone, I.

AU - La Rosa, F.

AU - Lillini, L.

AU - Madeddu, A.

AU - Magoni, M.

AU - Mangone, L.

AU - Manno, V.

AU - Marcello, I.

AU - Marinaccio, A.

AU - Marsili, G.

AU - Maspero, S.

AU - Maule, M.

AU - Mazzoleni, G.

AU - Merletti, F.

AU - Minelli, G.

AU - Minerba, A.

AU - Michiara, M.

AU - Nicita, C.

AU - Pannozzo, F.

AU - Pasetto, R.

AU - Piccardi, A.

AU - Piffer, S.

AU - Pirastu, R.

AU - Pisani, P.

AU - Ricci, P.

AU - Santoro, M.

AU - Scaini, F.

AU - Sciacca, S.

AU - Sechi, O.

AU - Serraino, D.

AU - Soggiu, M. E.

AU - Stracci, F.

AU - Sardo, A. Sutera

AU - Tagliabue, G.

AU - Tisano, F.

AU - Usala, M.

AU - Vercelli, M.

AU - Vitale, F.

AU - Vitarelli, S.

AU - Zambon, P.

AU - Zona, A.

PY - 2014

Y1 - 2014

N2 - Introduction: The incidence of cancer among residents in sites contaminated by pollutants with a possible health impact is not adequately studied. In Italy, SENTIERI Project (Epidemiological study of residents in National Priority Contaminated Sites, NPCSs) was implemented to study major health outcomes for residents in 44 NPCSs. Methods: The Italian Association of Cancer Registries (AIRTUM) records cancer incidence in 23 NPCSs. For each NPCSs, the incidence of all malignant cancers combined and 35 cancer sites (coded according to ICD-10), was analysed (1996-2005). The observed cases were compared to the expected based on age (5-year period, 18 classes), gender, calendar period (1996-2000; 2001-2005), geographical area (North-Centre and Centre-South) and cancer sites specific rates. Standardized Incidence Ratios (SIR) with 90% Confidence Intervals were computed. Results: In both genders an excess was observed for overall cancer incidence (9% in men and 7% in women) as well as for specific cancer sites (colon and rectum, liver, gallbladder, pancreas, lung, skin melanoma, bladder and Non Hodgkin lymphoma). Deficits were observed for gastric cancer in both genders, chronic lymphoid leukemia (men), malignant thyroid neoplasms, corpus uteri and connective and soft-tissue tumours and sarcomas (women). Discussion: This report is, to our knowledge, the first one on cancer risk of residents in NPCSs. The study, although not aiming to estimate the cancer burden attributable to the environment as compared to occupation or life-style, supports the credibility of an etiologic role of environmental exposures in contaminated sites. Ongoing analyses focus on the interpretation of risk factors for excesses of specific cancer types overall and in specific NPCSs in relation to the presence of carcinogenic pollutants.

AB - Introduction: The incidence of cancer among residents in sites contaminated by pollutants with a possible health impact is not adequately studied. In Italy, SENTIERI Project (Epidemiological study of residents in National Priority Contaminated Sites, NPCSs) was implemented to study major health outcomes for residents in 44 NPCSs. Methods: The Italian Association of Cancer Registries (AIRTUM) records cancer incidence in 23 NPCSs. For each NPCSs, the incidence of all malignant cancers combined and 35 cancer sites (coded according to ICD-10), was analysed (1996-2005). The observed cases were compared to the expected based on age (5-year period, 18 classes), gender, calendar period (1996-2000; 2001-2005), geographical area (North-Centre and Centre-South) and cancer sites specific rates. Standardized Incidence Ratios (SIR) with 90% Confidence Intervals were computed. Results: In both genders an excess was observed for overall cancer incidence (9% in men and 7% in women) as well as for specific cancer sites (colon and rectum, liver, gallbladder, pancreas, lung, skin melanoma, bladder and Non Hodgkin lymphoma). Deficits were observed for gastric cancer in both genders, chronic lymphoid leukemia (men), malignant thyroid neoplasms, corpus uteri and connective and soft-tissue tumours and sarcomas (women). Discussion: This report is, to our knowledge, the first one on cancer risk of residents in NPCSs. The study, although not aiming to estimate the cancer burden attributable to the environment as compared to occupation or life-style, supports the credibility of an etiologic role of environmental exposures in contaminated sites. Ongoing analyses focus on the interpretation of risk factors for excesses of specific cancer types overall and in specific NPCSs in relation to the presence of carcinogenic pollutants.

KW - Cancer incidence

KW - Contaminated sites

KW - Environmental pollution

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