Abstract
Different stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR). UPR is therefore involved in tumor growth and adaptation to severe environments and is generally cytoprotective in cancer. The present review describes the molecular mechanisms underlying UPR and able to promote survival and proliferation in cancer. The critical role of UPR activation in tumor growth promotion is discussed in detail for a few paradigmatic tumors such as prostate cancer and melanoma.
| Original language | English |
|---|---|
| Article number | 417281 |
| Journal | Mediators of Inflammation |
| Volume | 2015 |
| DOIs | |
| Publication status | Published - 2015 |
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ASJC Scopus subject areas
- Immunology
- Cell Biology
Cite this
Cancer microenvironment and endoplasmic reticulum stress response. / Giampietri, Claudia; Petrungaro, Simonetta; Conti, Silvia; Facchiano, Antonio; Filippini, Antonio; Ziparo, Elio.
In: Mediators of Inflammation, Vol. 2015, 417281, 2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cancer microenvironment and endoplasmic reticulum stress response
AU - Giampietri, Claudia
AU - Petrungaro, Simonetta
AU - Conti, Silvia
AU - Facchiano, Antonio
AU - Filippini, Antonio
AU - Ziparo, Elio
PY - 2015
Y1 - 2015
N2 - Different stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR). UPR is therefore involved in tumor growth and adaptation to severe environments and is generally cytoprotective in cancer. The present review describes the molecular mechanisms underlying UPR and able to promote survival and proliferation in cancer. The critical role of UPR activation in tumor growth promotion is discussed in detail for a few paradigmatic tumors such as prostate cancer and melanoma.
AB - Different stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR). UPR is therefore involved in tumor growth and adaptation to severe environments and is generally cytoprotective in cancer. The present review describes the molecular mechanisms underlying UPR and able to promote survival and proliferation in cancer. The critical role of UPR activation in tumor growth promotion is discussed in detail for a few paradigmatic tumors such as prostate cancer and melanoma.
UR - http://www.scopus.com/inward/record.url?scp=84944474385&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84944474385&partnerID=8YFLogxK
U2 - 10.1155/2015/417281
DO - 10.1155/2015/417281
M3 - Article
AN - SCOPUS:84944474385
VL - 2015
JO - Mediators of Inflammation
JF - Mediators of Inflammation
SN - 0962-9351
M1 - 417281
ER -