Cancer mortality in an international cohort of workers exposed to styrene.

M. Kogevinas, G. Ferro, R. Saracci, A. Andersen, M. Biocca, D. Coggon, V. Gennaro, S. Hutchings, H. Kolstad, I. Lundberg

Research output: Contribution to journalArticle

Abstract

Increased risks for leukaemia and lymphoma have been suggested in studies of workers exposed to styrene in the rubber and plastics industry. A historical cohort study was conducted in Denmark, Finland, Italy, Norway, Sweden and the United Kingdom involving 40,683 workers employed in the reinforced plastics industry, where high exposure to styrene occurs. Exposure to styrene was reconstructed through job histories, environmental and biological monitoring data and production records of the plants in the study. Cause-specific national death rates were used as the reference. Among exposed workers, no excess was observed for mortality from all causes (2195 deaths, standardized mortality ratio [SMR], 95; 95% confidence interval [CI], 91-99), from all neoplasms, from lung cancer or from other major epithelial cancers. Mortality from neoplasms of the lymphatic and haematopoietic tissues was not elevated (50 deaths; SMR, 96; CI, 71-126) and was not consistently associated with length of exposure. The rate of mortality from leukaemias and lymphomas increased with time since first exposure. Among subjects who had been exposed for more than one year, a two-fold risk was observed 20 years after first exposure (eight deaths; SMR, 197; CI, 85-387). These results are inadequate to exclude the possibility that styrene causes leukaemia and lymphoma.

Original languageEnglish
Pages (from-to)289-300
Number of pages12
JournalIARC scientific publications
Issue number127
Publication statusPublished - 1993

Fingerprint

Styrene
Mortality
Neoplasms
Lymphoma
Leukemia
Environmental Monitoring
Confidence Intervals
Plastics
Industry
Rubber
Lymphoid Tissue
Hematologic Neoplasms
Denmark
Finland
Norway
Sweden
Italy
Cause of Death
Lung Neoplasms
Cohort Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kogevinas, M., Ferro, G., Saracci, R., Andersen, A., Biocca, M., Coggon, D., ... Lundberg, I. (1993). Cancer mortality in an international cohort of workers exposed to styrene. IARC scientific publications, (127), 289-300.

Cancer mortality in an international cohort of workers exposed to styrene. / Kogevinas, M.; Ferro, G.; Saracci, R.; Andersen, A.; Biocca, M.; Coggon, D.; Gennaro, V.; Hutchings, S.; Kolstad, H.; Lundberg, I.

In: IARC scientific publications, No. 127, 1993, p. 289-300.

Research output: Contribution to journalArticle

Kogevinas, M, Ferro, G, Saracci, R, Andersen, A, Biocca, M, Coggon, D, Gennaro, V, Hutchings, S, Kolstad, H & Lundberg, I 1993, 'Cancer mortality in an international cohort of workers exposed to styrene.', IARC scientific publications, no. 127, pp. 289-300.
Kogevinas M, Ferro G, Saracci R, Andersen A, Biocca M, Coggon D et al. Cancer mortality in an international cohort of workers exposed to styrene. IARC scientific publications. 1993;(127):289-300.
Kogevinas, M. ; Ferro, G. ; Saracci, R. ; Andersen, A. ; Biocca, M. ; Coggon, D. ; Gennaro, V. ; Hutchings, S. ; Kolstad, H. ; Lundberg, I. / Cancer mortality in an international cohort of workers exposed to styrene. In: IARC scientific publications. 1993 ; No. 127. pp. 289-300.
@article{943d32d4df3d4095bfd57f27e07eb329,
title = "Cancer mortality in an international cohort of workers exposed to styrene.",
abstract = "Increased risks for leukaemia and lymphoma have been suggested in studies of workers exposed to styrene in the rubber and plastics industry. A historical cohort study was conducted in Denmark, Finland, Italy, Norway, Sweden and the United Kingdom involving 40,683 workers employed in the reinforced plastics industry, where high exposure to styrene occurs. Exposure to styrene was reconstructed through job histories, environmental and biological monitoring data and production records of the plants in the study. Cause-specific national death rates were used as the reference. Among exposed workers, no excess was observed for mortality from all causes (2195 deaths, standardized mortality ratio [SMR], 95; 95{\%} confidence interval [CI], 91-99), from all neoplasms, from lung cancer or from other major epithelial cancers. Mortality from neoplasms of the lymphatic and haematopoietic tissues was not elevated (50 deaths; SMR, 96; CI, 71-126) and was not consistently associated with length of exposure. The rate of mortality from leukaemias and lymphomas increased with time since first exposure. Among subjects who had been exposed for more than one year, a two-fold risk was observed 20 years after first exposure (eight deaths; SMR, 197; CI, 85-387). These results are inadequate to exclude the possibility that styrene causes leukaemia and lymphoma.",
author = "M. Kogevinas and G. Ferro and R. Saracci and A. Andersen and M. Biocca and D. Coggon and V. Gennaro and S. Hutchings and H. Kolstad and I. Lundberg",
year = "1993",
language = "English",
pages = "289--300",
journal = "IARC (International Agency for Research on Cancer) Scientific Publications",
issn = "0300-5038",
publisher = "IARC",
number = "127",

}

TY - JOUR

T1 - Cancer mortality in an international cohort of workers exposed to styrene.

AU - Kogevinas, M.

AU - Ferro, G.

AU - Saracci, R.

AU - Andersen, A.

AU - Biocca, M.

AU - Coggon, D.

AU - Gennaro, V.

AU - Hutchings, S.

AU - Kolstad, H.

AU - Lundberg, I.

PY - 1993

Y1 - 1993

N2 - Increased risks for leukaemia and lymphoma have been suggested in studies of workers exposed to styrene in the rubber and plastics industry. A historical cohort study was conducted in Denmark, Finland, Italy, Norway, Sweden and the United Kingdom involving 40,683 workers employed in the reinforced plastics industry, where high exposure to styrene occurs. Exposure to styrene was reconstructed through job histories, environmental and biological monitoring data and production records of the plants in the study. Cause-specific national death rates were used as the reference. Among exposed workers, no excess was observed for mortality from all causes (2195 deaths, standardized mortality ratio [SMR], 95; 95% confidence interval [CI], 91-99), from all neoplasms, from lung cancer or from other major epithelial cancers. Mortality from neoplasms of the lymphatic and haematopoietic tissues was not elevated (50 deaths; SMR, 96; CI, 71-126) and was not consistently associated with length of exposure. The rate of mortality from leukaemias and lymphomas increased with time since first exposure. Among subjects who had been exposed for more than one year, a two-fold risk was observed 20 years after first exposure (eight deaths; SMR, 197; CI, 85-387). These results are inadequate to exclude the possibility that styrene causes leukaemia and lymphoma.

AB - Increased risks for leukaemia and lymphoma have been suggested in studies of workers exposed to styrene in the rubber and plastics industry. A historical cohort study was conducted in Denmark, Finland, Italy, Norway, Sweden and the United Kingdom involving 40,683 workers employed in the reinforced plastics industry, where high exposure to styrene occurs. Exposure to styrene was reconstructed through job histories, environmental and biological monitoring data and production records of the plants in the study. Cause-specific national death rates were used as the reference. Among exposed workers, no excess was observed for mortality from all causes (2195 deaths, standardized mortality ratio [SMR], 95; 95% confidence interval [CI], 91-99), from all neoplasms, from lung cancer or from other major epithelial cancers. Mortality from neoplasms of the lymphatic and haematopoietic tissues was not elevated (50 deaths; SMR, 96; CI, 71-126) and was not consistently associated with length of exposure. The rate of mortality from leukaemias and lymphomas increased with time since first exposure. Among subjects who had been exposed for more than one year, a two-fold risk was observed 20 years after first exposure (eight deaths; SMR, 197; CI, 85-387). These results are inadequate to exclude the possibility that styrene causes leukaemia and lymphoma.

UR - http://www.scopus.com/inward/record.url?scp=0027828444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027828444&partnerID=8YFLogxK

M3 - Article

C2 - 8070875

AN - SCOPUS:0027828444

SP - 289

EP - 300

JO - IARC (International Agency for Research on Cancer) Scientific Publications

JF - IARC (International Agency for Research on Cancer) Scientific Publications

SN - 0300-5038

IS - 127

ER -