Cancer mortality in Córdoba, Argentina, 1986-2006: An age-period-cohort analysis

Sonia Alejandra Pou, A. R. Osella, Aldo Renato Eynard, María Del Pilar Diaz

Research output: Contribution to journalArticlepeer-review


Aims and background. Cancer is the second main cause of death in Argentina, surpassed only by cardiovascular disease.However, analytical approaches isolating some of the known effects, such as age at death, period of death and birth cohort, have never been performed in cancermortality studies in Argentina. The aimof this study was to analyze cancer mortality trends in a representative region of the country, the Córdoba province (1986-2006). Methods and study design. Overall age-standardized (world population) mortality rates for cancer (all sites) were computed by a direct method. Joinpoint regression was fitted to the age-standardized mortality rates for both sexes to provide estimated and 95%confidence intervals of the annual percentage changes. The effects of age (15 age groups), period of death (1986-90, 1991-95, 1996-00 or 2001-06), and birth cohort (18 overlapping 10-year birth cohorts) covariates on mortality rates were estimated using a sequentially fitted Poisson regression model. Results. During the study period, 102,737 people died of cancer in Córdoba, with the age-standardized mortality rates decreasing from 139.3 to 118.7/100,000 person-years. Although this reduction was more noticeable in men, the joinpoint regression model showed a significant change of the age-standardizedmortality rates after 1996 in both sexes. Age-period-cohort analysis suggested that the cancer mortality trends may be linked with a strong age effect and a moderate or mild period and cohort effect, related to sex and place of residence. Conclusions. Based on the observed cohort effect, itmay be argued that there has been a lower exposure level to some risk factors, such as diet and other environmental factors, in Cordoba over the last decades.

Original languageEnglish
Pages (from-to)202-212
Number of pages11
Issue number2
Publication statusPublished - Mar 2010


  • Age-period-cohort model
  • Argentina
  • Cancer mortality
  • Cordoba

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


Dive into the research topics of 'Cancer mortality in Córdoba, Argentina, 1986-2006: An age-period-cohort analysis'. Together they form a unique fingerprint.

Cite this