Cancer nanomedicine special issue review anticancer drug delivery with nanoparticles: Extracellular vesicles or synthetic nanobeads as therapeutic tools for conventional treatment or immunotherapy

M.R. Zocchi, F. Tosetti, R. Benelli, A. Poggi

Research output: Contribution to journalArticlepeer-review

Abstract

Both natural and synthetic nanoparticles have been proposed as drug carriers in cancer treatment, since they can increase drug accumulation in target tissues, optimizing the therapeutic effect. As an example, extracellular vesicles (EV), including exosomes (Exo), can become drug vehicles through endogenous or exogenous loading, amplifying the anticancer effects at the tumor site. In turn, synthetic nanoparticles (NP) can carry therapeutic molecules inside their core, improving solubility and stability, preventing degradation, and controlling their release. In this review, we summarize the recent advances in nanotechnology applied for theranostic use, distinguishing between passive and active targeting of these vehicles. In addition, examples of these models are reported: EV as transporters of conventional anticancer drugs; Exo or NP as carriers of small molecules that induce an anti-tumor immune response. Finally, we focus on two types of nanoparticles used to stimulate an anticancer immune response: Exo carried with A Disintegrin And Metalloprotease-10 inhibitors and NP loaded with aminobisphosphonates. The former would reduce the release of decoy ligands that impair tumor cell recognition, while the latter would activate the peculiar anti-tumor response exerted by γδ T cells, creating a bridge between innate and adaptive immunity. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Original languageEnglish
Pages (from-to)1-32
Number of pages32
JournalCancers
Volume12
Issue number7
DOIs
Publication statusPublished - 2020

Keywords

  • ADAM10
  • Alendronic acid
  • Aminobisphosphonates
  • Exosomes
  • Polymeric nanoparticles
  • Zoledronic acid
  • ADAM10 endopeptidase
  • ADAM10 inhibitor
  • alendronic acid
  • aminobisphosphonate derivative
  • antineoplastic agent
  • bisphosphonic acid derivative
  • clodronic acid
  • drug carrier
  • nanobead
  • nanocarrier
  • protein inhibitor
  • unclassified drug
  • zoledronic acid
  • adaptive immunity
  • antineoplastic activity
  • Article
  • cancer immunization
  • cancer immunotherapy
  • cell communication
  • chemical modification
  • drug delivery system
  • drug formulation
  • exosome
  • gamma delta T lymphocyte
  • human
  • immunosurveillance
  • innate immunity
  • murine model
  • nanotechnology
  • nonhuman
  • pathophysiology
  • surface property
  • theranostic nanomedicine
  • tumor immunity

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