In this series, it seems that after chemotherapy at least some tissues which were previously invaded by cancer may remain free from tumor cells over a period of time certainly longer than the authors have so far thought possible on the basis of their knowledge of antiblastic chemotherapy. Since these tissues correspond to the periphery of the cancer, one can reasonably assume that chemotherapy operates more effectively in this area owing to a better vascularization, a higher concentration of the drug and, subsequently, a more effective biological intervention of the surrounding healthy tissues against isolated and suffering cells. Such an interpretation deserves further investigation. At present, their findings do not authorize any diminution of the amount of tissue to be removed after chemotherapy, so that, when a radical operation is feasible, the cut line must be adjusted to the previous size of the tumor. Nonetheless, if a radical procedure according to this principle is not possible, a removal as radical as possible of the residual cancer is justified, provided that the tumor shrinkage was marked (at least 50%); and lymph node metastases are absent or minimal and rationally treatable.
|Title of host publication||EXCERPTA MEDICA|
|Number of pages||4|
|Publication status||Published - 1975|
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