Cancer of the low and middle rectum: Local and distant recurrences, and survival in 350 radically resected patients

Federico Bozzetti, Luigi Mariani, Rosalba Miceli, Roberto Doci, Fabrizio Montalto, Salvatore Andreola, Leandro Gennari

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to compare local recurrence, distant metastases, and survival rate in 350 patients with cancer of the middle and low rectum who underwent a radical abdominoperineal resection (APER) or a sphincter-saving resection (SSR) in our Institute. There were 257 APER patients and 93 SSR patients, with a median follow-up of 77 months. At 5 years, the estimates in APER and SSR patients were respectively 11% and 30% for the incidence of pelvic recurrence, 18% and 8% for the incidence of distant metastases, and 64% and 73% for overall survival. In the multivariate analysis it was found that Dukes' stage significantly affected pelvic recurrences, distant metastases rate and overall survival; histologic type affected only the pelvic recurrence rate. However, the final outcome of patients following APER or SSR was similar, suggesting that local failure per se does not affect long-term survival.

Original languageEnglish
Pages (from-to)207-213
Number of pages7
JournalJournal of Surgical Oncology
Volume62
Issue number3
DOIs
Publication statusPublished - Jul 1996

Keywords

  • abdominoperineal resection
  • rectal cancer
  • sphincter-saving surgery

ASJC Scopus subject areas

  • Surgery
  • Oncology

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