Abstract
The purpose of this study was to compare local recurrence, distant metastases, and survival rate in 350 patients with cancer of the middle and low rectum who underwent a radical abdominoperineal resection (APER) or a sphincter-saving resection (SSR) in our Institute. There were 257 APER patients and 93 SSR patients, with a median follow-up of 77 months. At 5 years, the estimates in APER and SSR patients were respectively 11% and 30% for the incidence of pelvic recurrence, 18% and 8% for the incidence of distant metastases, and 64% and 73% for overall survival. In the multivariate analysis it was found that Dukes' stage significantly affected pelvic recurrences, distant metastases rate and overall survival; histologic type affected only the pelvic recurrence rate. However, the final outcome of patients following APER or SSR was similar, suggesting that local failure per se does not affect long-term survival.
| Original language | English |
|---|---|
| Pages (from-to) | 207-213 |
| Number of pages | 7 |
| Journal | Journal of Surgical Oncology |
| Volume | 62 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 1996 |
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Keywords
- abdominoperineal resection
- rectal cancer
- sphincter-saving surgery
ASJC Scopus subject areas
- Surgery
- Oncology
Cite this
Cancer of the low and middle rectum : Local and distant recurrences, and survival in 350 radically resected patients. / Bozzetti, Federico; Mariani, Luigi; Miceli, Rosalba; Doci, Roberto; Montalto, Fabrizio; Andreola, Salvatore; Gennari, Leandro.
In: Journal of Surgical Oncology, Vol. 62, No. 3, 07.1996, p. 207-213.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cancer of the low and middle rectum
T2 - Local and distant recurrences, and survival in 350 radically resected patients
AU - Bozzetti, Federico
AU - Mariani, Luigi
AU - Miceli, Rosalba
AU - Doci, Roberto
AU - Montalto, Fabrizio
AU - Andreola, Salvatore
AU - Gennari, Leandro
PY - 1996/7
Y1 - 1996/7
N2 - The purpose of this study was to compare local recurrence, distant metastases, and survival rate in 350 patients with cancer of the middle and low rectum who underwent a radical abdominoperineal resection (APER) or a sphincter-saving resection (SSR) in our Institute. There were 257 APER patients and 93 SSR patients, with a median follow-up of 77 months. At 5 years, the estimates in APER and SSR patients were respectively 11% and 30% for the incidence of pelvic recurrence, 18% and 8% for the incidence of distant metastases, and 64% and 73% for overall survival. In the multivariate analysis it was found that Dukes' stage significantly affected pelvic recurrences, distant metastases rate and overall survival; histologic type affected only the pelvic recurrence rate. However, the final outcome of patients following APER or SSR was similar, suggesting that local failure per se does not affect long-term survival.
AB - The purpose of this study was to compare local recurrence, distant metastases, and survival rate in 350 patients with cancer of the middle and low rectum who underwent a radical abdominoperineal resection (APER) or a sphincter-saving resection (SSR) in our Institute. There were 257 APER patients and 93 SSR patients, with a median follow-up of 77 months. At 5 years, the estimates in APER and SSR patients were respectively 11% and 30% for the incidence of pelvic recurrence, 18% and 8% for the incidence of distant metastases, and 64% and 73% for overall survival. In the multivariate analysis it was found that Dukes' stage significantly affected pelvic recurrences, distant metastases rate and overall survival; histologic type affected only the pelvic recurrence rate. However, the final outcome of patients following APER or SSR was similar, suggesting that local failure per se does not affect long-term survival.
KW - abdominoperineal resection
KW - rectal cancer
KW - sphincter-saving surgery
UR - http://www.scopus.com/inward/record.url?scp=0029903314&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029903314&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1096-9098(199607)62:3<207::AID-JSO11>3.0.CO;2-3
DO - 10.1002/(SICI)1096-9098(199607)62:3<207::AID-JSO11>3.0.CO;2-3
M3 - Article
C2 - 8667629
AN - SCOPUS:0029903314
VL - 62
SP - 207
EP - 213
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 3
ER -