Cancer of the low and middle rectum: Local and distant recurrences, and survival in 350 radically resected patients

Federico Bozzetti, Luigi Mariani, Rosalba Miceli, Roberto Doci, Fabrizio Montalto, Salvatore Andreola, Leandro Gennari

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to compare local recurrence, distant metastases, and survival rate in 350 patients with cancer of the middle and low rectum who underwent a radical abdominoperineal resection (APER) or a sphincter-saving resection (SSR) in our Institute. There were 257 APER patients and 93 SSR patients, with a median follow-up of 77 months. At 5 years, the estimates in APER and SSR patients were respectively 11% and 30% for the incidence of pelvic recurrence, 18% and 8% for the incidence of distant metastases, and 64% and 73% for overall survival. In the multivariate analysis it was found that Dukes' stage significantly affected pelvic recurrences, distant metastases rate and overall survival; histologic type affected only the pelvic recurrence rate. However, the final outcome of patients following APER or SSR was similar, suggesting that local failure per se does not affect long-term survival.

Original languageEnglish
Pages (from-to)207-213
Number of pages7
JournalJournal of Surgical Oncology
Volume62
Issue number3
DOIs
Publication statusPublished - Jul 1996

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Rectum
Recurrence
Survival
Neoplasms
Neoplasm Metastasis
Survival Rate
Incidence
Multivariate Analysis

Keywords

  • abdominoperineal resection
  • rectal cancer
  • sphincter-saving surgery

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Cancer of the low and middle rectum : Local and distant recurrences, and survival in 350 radically resected patients. / Bozzetti, Federico; Mariani, Luigi; Miceli, Rosalba; Doci, Roberto; Montalto, Fabrizio; Andreola, Salvatore; Gennari, Leandro.

In: Journal of Surgical Oncology, Vol. 62, No. 3, 07.1996, p. 207-213.

Research output: Contribution to journalArticle

Bozzetti, Federico ; Mariani, Luigi ; Miceli, Rosalba ; Doci, Roberto ; Montalto, Fabrizio ; Andreola, Salvatore ; Gennari, Leandro. / Cancer of the low and middle rectum : Local and distant recurrences, and survival in 350 radically resected patients. In: Journal of Surgical Oncology. 1996 ; Vol. 62, No. 3. pp. 207-213.
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