Cancer of the prostate

Sergio Bracarda, Ottavio De Cobelli, Carlo Greco, Tommaso Prayer-Galetti, Riccardo Valdagni, Gemma Gatta, Filippo De Braud, Georg Bartsch

Research output: Contribution to journalArticlepeer-review


Prostate carcinoma, with about 190,000 new cases occurring each year (15% of all cancers in men), is the most frequent cancer among men in northern and western Europe. Causes of the disease are essentially unknown, although hormonal factors are involved, and diet may exert an indirect influence; some genes, potentially involved in hereditary prostate cancer (HPC) have been identified. A suspect of prostate cancer may derive from elevated serum prostate-specific antigen (PSA) values and/or a suspicious digital rectal examination (DRE) finding. For a definitive diagnosis, however, a positive prostate biopsy is requested. Treatment strategy is defined according to initial PSA stage, and grade of the disease and age and general conditions of the patient. In localized disease, watchful waiting is indicated as primary option in patients with well or moderately differentiated tumours and a life expectancy

Original languageEnglish
Pages (from-to)379-396
Number of pages18
JournalCritical Reviews in Oncology/Hematology
Issue number3
Publication statusPublished - Dec 2005


  • Chemotherapy
  • Follow-up
  • Hormone-therapy
  • Prostate neoplasms
  • Prostate-specific antigen
  • Radical prostatectomy
  • Radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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