Cancer predictive value of cytogenetic markers used in occupational health surveillance programs.

L. Hagmar, S. Bonassi, U. Strömberg, Z. Mikoczy, C. Lando, I. L. Hansteen, A. H. Montagud, L. Knudsen, H. Norppa, C. Reuterwall, H. Tinnerberg, A. Brøgger, A. Forni, B. Högstedt, B. Lambert, F. Mitelman, I. Nordenson, S. Salomaa, S. Skerfving

Research output: Contribution to journalArticlepeer-review

Abstract

It has not previously been clear whether cytogenetic biomarkers in healthy subjects will predict cancer. Earlier analyses of a Nordic and an Italian cohort indicated predictivity for chromosomal aberrations (CAS) but not for sister chromatid exchanges (SCES). A pooled analysis of the updated cohorts, forming a joint study base of 5271 subjects, will now be performed, allowing a more solid evaluation. The importance of potential effect modifiers, such as gender, age at testing, and time since testing, will be evaluated using Poisson regression models. Two other potential effect modifiers, occupational exposures and smoking, will be assessed in a case-referent study within the study base.

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalRecent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
Volume154
Publication statusPublished - 1998

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