Cancer-promoting tumor-associated macrophages: New vistas and open questions

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Abstract

Tumor-associated macrophages (TAMs) are key components of the tumor macroenvironment. Cancer- and host cell-derived signals generally drive the functions of TAMs towards an M2-like polarized, tumor-propelling mode; however, when appropriately re-educated. TAMs also have the potential to elicit tumor destructive reactions. Here, we discuss recent advances regarding the immunobiology of TAMs and highlight open questions including the mechanisms of their accumulation (recruitment versus proliferation), their diversity and how to best therapeutically target these cells.

Original languageEnglish
Pages (from-to)2522-2525
Number of pages4
JournalEuropean Journal of Immunology
Volume41
Issue number9
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Cancer
  • Chemokines
  • Inflammation
  • Macrophages
  • Tumor-associated macrophages

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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