Cancer rates after year 2000 significantly decrease in children with perinatal HIV infection: A study by the Italian Register for HIV Infection in Children

Elena Chiappini, Luisa Galli, Pier Angelo Tovo, Clara Gabiano, Catiuscia Lisi, Carlo Giaquinto, Osvalda Rampon, Guido Castelli Gattinara, Giulio De Marco, Patrizia Osimani, Mariano Manzionna, Angela Miniaci, Carlo Pintor, Raffaella Rosso, Susanna Esposito, Alessandra Viganò, Icilio Dodi, Anna Maccabruni, Carlo Fundarò, Maurizio De Martino

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Abstract

Purpose: To evaluate the impact of highly active antiretroviral therapy (HAART) on cancer incidence in HIV-infected children throughout a 20-year period. Patients and Methods: An observational population study was conducted on 1,190 perinatally HIV-infected children enrolled onto the Italian Register for HIV Infection in Children from 1985 to 2004 and never lost to follow-up (total observation time, 10,037.66 years). Cancer rates were calculated in the pre-HAART (1985 to 1995), early HAART (1996 to 1999), and late HAART (2000 to 2004) periods and compared using Poisson regression adjusted for age. The proportion of HAART-treated children increased from 4.1% in 1996 to 60.4% in 1999 and to 81.5% in 2004. In the same time frame, the proportion of children receiving HAART for at least 2 years increased from 3.1% to 77.0%. Results: Overall, 35 cancers occurred. Cancer rates were 4.49 (95% CI, 2.37 to 6.64), 4.09 (95% CI, 1.68 to 6.50), and 0.76 (95% CI, 0.00 to 1.80) per 1,000 children per year in 1985 to 1995, 1996 to 1999, and 2000 to 2004, respectively. Notably, there was no significant difference comparing the periods from 1985 to 1995 and 1996 to 1999 (P = .081). By contrast, cancer rates were significantly lower in the period from 2000 to 2004 than in 1996 to 1999 (P <.0001). Results were confirmed by separately analyzing data from children observed from birth (P = .418 for 1985 to 1995 v 1996 to 1999; P = .001 for 1996 to 1999 v 2000 to 2004). Conclusion: Dramatically reduced cancer rates were observed only in the late HAART period in parallel to the increasing proportion of children receiving HAART therapy.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalJournal of Clinical Oncology
Volume25
Issue number1
DOIs
Publication statusPublished - Jan 1 2007

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Highly Active Antiretroviral Therapy
HIV Infections
Neoplasms
HIV
Lost to Follow-Up
Secondary Prevention
Observational Studies
Observation
Parturition
Incidence
Population

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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Cancer rates after year 2000 significantly decrease in children with perinatal HIV infection : A study by the Italian Register for HIV Infection in Children. / Chiappini, Elena; Galli, Luisa; Tovo, Pier Angelo; Gabiano, Clara; Lisi, Catiuscia; Giaquinto, Carlo; Rampon, Osvalda; Gattinara, Guido Castelli; De Marco, Giulio; Osimani, Patrizia; Manzionna, Mariano; Miniaci, Angela; Pintor, Carlo; Rosso, Raffaella; Esposito, Susanna; Viganò, Alessandra; Dodi, Icilio; Maccabruni, Anna; Fundarò, Carlo; De Martino, Maurizio.

In: Journal of Clinical Oncology, Vol. 25, No. 1, 01.01.2007, p. 97-101.

Research output: Contribution to journalArticle

Chiappini, E, Galli, L, Tovo, PA, Gabiano, C, Lisi, C, Giaquinto, C, Rampon, O, Gattinara, GC, De Marco, G, Osimani, P, Manzionna, M, Miniaci, A, Pintor, C, Rosso, R, Esposito, S, Viganò, A, Dodi, I, Maccabruni, A, Fundarò, C & De Martino, M 2007, 'Cancer rates after year 2000 significantly decrease in children with perinatal HIV infection: A study by the Italian Register for HIV Infection in Children', Journal of Clinical Oncology, vol. 25, no. 1, pp. 97-101. https://doi.org/10.1200/JCO.2006.06.6506
Chiappini, Elena ; Galli, Luisa ; Tovo, Pier Angelo ; Gabiano, Clara ; Lisi, Catiuscia ; Giaquinto, Carlo ; Rampon, Osvalda ; Gattinara, Guido Castelli ; De Marco, Giulio ; Osimani, Patrizia ; Manzionna, Mariano ; Miniaci, Angela ; Pintor, Carlo ; Rosso, Raffaella ; Esposito, Susanna ; Viganò, Alessandra ; Dodi, Icilio ; Maccabruni, Anna ; Fundarò, Carlo ; De Martino, Maurizio. / Cancer rates after year 2000 significantly decrease in children with perinatal HIV infection : A study by the Italian Register for HIV Infection in Children. In: Journal of Clinical Oncology. 2007 ; Vol. 25, No. 1. pp. 97-101.
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abstract = "Purpose: To evaluate the impact of highly active antiretroviral therapy (HAART) on cancer incidence in HIV-infected children throughout a 20-year period. Patients and Methods: An observational population study was conducted on 1,190 perinatally HIV-infected children enrolled onto the Italian Register for HIV Infection in Children from 1985 to 2004 and never lost to follow-up (total observation time, 10,037.66 years). Cancer rates were calculated in the pre-HAART (1985 to 1995), early HAART (1996 to 1999), and late HAART (2000 to 2004) periods and compared using Poisson regression adjusted for age. The proportion of HAART-treated children increased from 4.1{\%} in 1996 to 60.4{\%} in 1999 and to 81.5{\%} in 2004. In the same time frame, the proportion of children receiving HAART for at least 2 years increased from 3.1{\%} to 77.0{\%}. Results: Overall, 35 cancers occurred. Cancer rates were 4.49 (95{\%} CI, 2.37 to 6.64), 4.09 (95{\%} CI, 1.68 to 6.50), and 0.76 (95{\%} CI, 0.00 to 1.80) per 1,000 children per year in 1985 to 1995, 1996 to 1999, and 2000 to 2004, respectively. Notably, there was no significant difference comparing the periods from 1985 to 1995 and 1996 to 1999 (P = .081). By contrast, cancer rates were significantly lower in the period from 2000 to 2004 than in 1996 to 1999 (P <.0001). Results were confirmed by separately analyzing data from children observed from birth (P = .418 for 1985 to 1995 v 1996 to 1999; P = .001 for 1996 to 1999 v 2000 to 2004). Conclusion: Dramatically reduced cancer rates were observed only in the late HAART period in parallel to the increasing proportion of children receiving HAART therapy.",
author = "Elena Chiappini and Luisa Galli and Tovo, {Pier Angelo} and Clara Gabiano and Catiuscia Lisi and Carlo Giaquinto and Osvalda Rampon and Gattinara, {Guido Castelli} and {De Marco}, Giulio and Patrizia Osimani and Mariano Manzionna and Angela Miniaci and Carlo Pintor and Raffaella Rosso and Susanna Esposito and Alessandra Vigan{\`o} and Icilio Dodi and Anna Maccabruni and Carlo Fundar{\`o} and {De Martino}, Maurizio",
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T1 - Cancer rates after year 2000 significantly decrease in children with perinatal HIV infection

T2 - A study by the Italian Register for HIV Infection in Children

AU - Chiappini, Elena

AU - Galli, Luisa

AU - Tovo, Pier Angelo

AU - Gabiano, Clara

AU - Lisi, Catiuscia

AU - Giaquinto, Carlo

AU - Rampon, Osvalda

AU - Gattinara, Guido Castelli

AU - De Marco, Giulio

AU - Osimani, Patrizia

AU - Manzionna, Mariano

AU - Miniaci, Angela

AU - Pintor, Carlo

AU - Rosso, Raffaella

AU - Esposito, Susanna

AU - Viganò, Alessandra

AU - Dodi, Icilio

AU - Maccabruni, Anna

AU - Fundarò, Carlo

AU - De Martino, Maurizio

PY - 2007/1/1

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N2 - Purpose: To evaluate the impact of highly active antiretroviral therapy (HAART) on cancer incidence in HIV-infected children throughout a 20-year period. Patients and Methods: An observational population study was conducted on 1,190 perinatally HIV-infected children enrolled onto the Italian Register for HIV Infection in Children from 1985 to 2004 and never lost to follow-up (total observation time, 10,037.66 years). Cancer rates were calculated in the pre-HAART (1985 to 1995), early HAART (1996 to 1999), and late HAART (2000 to 2004) periods and compared using Poisson regression adjusted for age. The proportion of HAART-treated children increased from 4.1% in 1996 to 60.4% in 1999 and to 81.5% in 2004. In the same time frame, the proportion of children receiving HAART for at least 2 years increased from 3.1% to 77.0%. Results: Overall, 35 cancers occurred. Cancer rates were 4.49 (95% CI, 2.37 to 6.64), 4.09 (95% CI, 1.68 to 6.50), and 0.76 (95% CI, 0.00 to 1.80) per 1,000 children per year in 1985 to 1995, 1996 to 1999, and 2000 to 2004, respectively. Notably, there was no significant difference comparing the periods from 1985 to 1995 and 1996 to 1999 (P = .081). By contrast, cancer rates were significantly lower in the period from 2000 to 2004 than in 1996 to 1999 (P <.0001). Results were confirmed by separately analyzing data from children observed from birth (P = .418 for 1985 to 1995 v 1996 to 1999; P = .001 for 1996 to 1999 v 2000 to 2004). Conclusion: Dramatically reduced cancer rates were observed only in the late HAART period in parallel to the increasing proportion of children receiving HAART therapy.

AB - Purpose: To evaluate the impact of highly active antiretroviral therapy (HAART) on cancer incidence in HIV-infected children throughout a 20-year period. Patients and Methods: An observational population study was conducted on 1,190 perinatally HIV-infected children enrolled onto the Italian Register for HIV Infection in Children from 1985 to 2004 and never lost to follow-up (total observation time, 10,037.66 years). Cancer rates were calculated in the pre-HAART (1985 to 1995), early HAART (1996 to 1999), and late HAART (2000 to 2004) periods and compared using Poisson regression adjusted for age. The proportion of HAART-treated children increased from 4.1% in 1996 to 60.4% in 1999 and to 81.5% in 2004. In the same time frame, the proportion of children receiving HAART for at least 2 years increased from 3.1% to 77.0%. Results: Overall, 35 cancers occurred. Cancer rates were 4.49 (95% CI, 2.37 to 6.64), 4.09 (95% CI, 1.68 to 6.50), and 0.76 (95% CI, 0.00 to 1.80) per 1,000 children per year in 1985 to 1995, 1996 to 1999, and 2000 to 2004, respectively. Notably, there was no significant difference comparing the periods from 1985 to 1995 and 1996 to 1999 (P = .081). By contrast, cancer rates were significantly lower in the period from 2000 to 2004 than in 1996 to 1999 (P <.0001). Results were confirmed by separately analyzing data from children observed from birth (P = .418 for 1985 to 1995 v 1996 to 1999; P = .001 for 1996 to 1999 v 2000 to 2004). Conclusion: Dramatically reduced cancer rates were observed only in the late HAART period in parallel to the increasing proportion of children receiving HAART therapy.

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