Cancer rejection by the immune system: Forcing the check-points of tumor immune escape

Simone Mocellin, Susanna Mandruzzato, Paola Zanovello, Vincenzo Bronte

Research output: Contribution to journalArticle

Abstract

Although the immune system can recognize and kill malignant cells, tumor immune surveillance or immunotherapy are largely insufficient in controlling cancer. The mechanisms underlying tumor immune escape are still to be fully dissected. An important emerging concept is that tumor and tumor-infiltrating host cells can alter the metabolism of some amino acids with a profound impact on antitumor immunity. Such mechanisms constitute potential check-points for tumor-specific T-lymphocytes, which must be considered in the design of novel immunotherapeutic approaches.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalDrug Discovery Today: Disease Mechanisms
Volume2
Issue number2
DOIs
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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