Cancer-related inflammation: Common themes and therapeutic opportunities

Frances R. Balkwill, Alberto Mantovani

Research output: Contribution to journalArticlepeer-review


Inflammatory cells and mediators are an essential component of the tumor microenvironment. Inflammatory circuits can differ considerably in different tumors in terms of cellular and cytokine networks and molecular drivers. However, macrophages are a common and fundamental component of cancer promoting inflammation. Drivers of macrophage functional orientation include tumor cells, cancer-associated fibroblasts, T cells and B cells. Dissection of the diversity of cancer-related inflammation is instrumental to the design of therapeutic approaches that target cancer-related inflammation.

Original languageEnglish
Pages (from-to)33-40
Number of pages8
JournalSeminars in Cancer Biology
Issue number1
Publication statusPublished - Feb 2012


  • Chemokines
  • Cytokines
  • Inflammation
  • Macrophages
  • Tumor microenvironment

ASJC Scopus subject areas

  • Cancer Research

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