Cancer related inflammation: The macrophage connection

Antonio Sica; Paola Allavena; Alberto Mantovani

doi:10.1016/j.canlet.2008.03.028

Cancer related inflammation: The macrophage connection

Antonio Sica, Paola Allavena, Alberto Mantovani

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.

Original language	English
Pages (from-to)	204-215
Number of pages	12
Journal	Cancer Letters
Volume	267
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2008.03.028
Publication status	Published - Aug 28 2008

Keywords

Angiogenesis
Cancer
Chemokines
Cytokines
Inflammation
Macrophage polarization
Therapeutic targets
Tumor promotion
Tumor-associated macrophages

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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abstract = "Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.",

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KW - Angiogenesis

KW - Cancer

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KW - Therapeutic targets

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