Cancer related inflammation: The macrophage connection

Antonio Sica; Paola Allavena; Alberto Mantovani

doi:10.1016/j.canlet.2008.03.028

Cancer related inflammation: The macrophage connection

Antonio Sica, Paola Allavena, Alberto Mantovani

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.

Original language	English
Pages (from-to)	204-215
Number of pages	12
Journal	Cancer Letters
Volume	267
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2008.03.028
Publication status	Published - Aug 28 2008

Keywords

Angiogenesis
Cancer
Chemokines
Cytokines
Inflammation
Macrophage polarization
Therapeutic targets
Tumor promotion
Tumor-associated macrophages

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

Access to Document

10.1016/j.canlet.2008.03.028

Cite this

@article{7fbb5ebcf33e4b03935a44768dc434bc,

title = "Cancer related inflammation: The macrophage connection",

abstract = "Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.",

keywords = "Angiogenesis, Cancer, Chemokines, Cytokines, Inflammation, Macrophage polarization, Therapeutic targets, Tumor promotion, Tumor-associated macrophages",

author = "Antonio Sica and Paola Allavena and Alberto Mantovani",

year = "2008",

month = aug,

day = "28",

doi = "10.1016/j.canlet.2008.03.028",

language = "English",

volume = "267",

pages = "204--215",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Cancer related inflammation

T2 - The macrophage connection

AU - Sica, Antonio

AU - Allavena, Paola

AU - Mantovani, Alberto

PY - 2008/8/28

Y1 - 2008/8/28

N2 - Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.

AB - Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.

KW - Angiogenesis

KW - Cancer

KW - Chemokines

KW - Cytokines

KW - Inflammation

KW - Macrophage polarization

KW - Therapeutic targets

KW - Tumor promotion

KW - Tumor-associated macrophages

UR - http://www.scopus.com/inward/record.url?scp=47749155653&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=47749155653&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2008.03.028

DO - 10.1016/j.canlet.2008.03.028

M3 - Article

C2 - 18448242

AN - SCOPUS:47749155653

VL - 267

SP - 204

EP - 215

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 2

ER -

Cancer related inflammation: The macrophage connection

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this