Abstract
Objective: To evaluate the cancer risk in southern European men with, or at risk of, HIV infection. Design: An analysis of longitudinal data to assess time-dependent rare events. Methods: Data from a cohort of HIV seroconverters, and from two hospital-based HIV seroprevalent cohorts were combined and analysed. The number of cancer cases observed was compared with the expected number, obtained from cancer incidence rates among men in the general population. Age-standardized incidence ratios (SIR) and their 95% confidence intervals (CI) were computed. Results: A total of 19,609 person-years of observation were accumulated among HIV-positive men, and 7957 person-years among HIV-negative men. Among HIV-positive men, statistically significant increased SIR were seen for Hodgkin's disease (HD) (SIR = 8.7), liver cancer (SIR = 11.0), and cancer of the salivary glands (SIR = 33.6). An excess of lung cancer was seen among intravenous drug users (IDU), but not among homosexual men. When the risk of all non-AIDS-defining cancers was considered, HIV-positive men had a nearly twofold excess (95% CI: 1.2-2.8). A risk of similar magnitude emerged among HIV-negative IDU (95% CI: 1.0-4.5), largely attributable to lung cancer and HD. Conclusion: These findings confirm that HIV infection increases the risk of HD, whereas they suggest that the risk of hepatocellular carcinoma may also be enhanced by HIV infection. The observation of an elevated risk of lung cancer in both HIV-positive and HIV-negative IDU points to personal behaviours unrelated to HIV infection. (C) 2000 Lippincott Williams and Wilkins.
| Original language | English |
|---|---|
| Pages (from-to) | 553-559 |
| Number of pages | 7 |
| Journal | AIDS (London, England) |
| Volume | 14 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2000 |
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Keywords
- Cancers
- Cohort study
- Drug users
- France
- HIV
- Italy
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Cancer risk among men with, or at risk of, HIV infection in southern Europe. / Serraino, Diego; Boschini, Antonio; Carrieri, Patrizia; Pradier, Christian; Dorrucci, Maria; Dal Maso, Luigino; Ballarini, Paolo; Pezzotti, Patrizio; Smacchia, Camillo; Pesce, Alain; Ippolito, Giuseppe; Franceschi, Silvia; Rezza, Giovanni.
In: AIDS (London, England), Vol. 14, No. 5, 2000, p. 553-559.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cancer risk among men with, or at risk of, HIV infection in southern Europe
AU - Serraino, Diego
AU - Boschini, Antonio
AU - Carrieri, Patrizia
AU - Pradier, Christian
AU - Dorrucci, Maria
AU - Dal Maso, Luigino
AU - Ballarini, Paolo
AU - Pezzotti, Patrizio
AU - Smacchia, Camillo
AU - Pesce, Alain
AU - Ippolito, Giuseppe
AU - Franceschi, Silvia
AU - Rezza, Giovanni
PY - 2000
Y1 - 2000
N2 - Objective: To evaluate the cancer risk in southern European men with, or at risk of, HIV infection. Design: An analysis of longitudinal data to assess time-dependent rare events. Methods: Data from a cohort of HIV seroconverters, and from two hospital-based HIV seroprevalent cohorts were combined and analysed. The number of cancer cases observed was compared with the expected number, obtained from cancer incidence rates among men in the general population. Age-standardized incidence ratios (SIR) and their 95% confidence intervals (CI) were computed. Results: A total of 19,609 person-years of observation were accumulated among HIV-positive men, and 7957 person-years among HIV-negative men. Among HIV-positive men, statistically significant increased SIR were seen for Hodgkin's disease (HD) (SIR = 8.7), liver cancer (SIR = 11.0), and cancer of the salivary glands (SIR = 33.6). An excess of lung cancer was seen among intravenous drug users (IDU), but not among homosexual men. When the risk of all non-AIDS-defining cancers was considered, HIV-positive men had a nearly twofold excess (95% CI: 1.2-2.8). A risk of similar magnitude emerged among HIV-negative IDU (95% CI: 1.0-4.5), largely attributable to lung cancer and HD. Conclusion: These findings confirm that HIV infection increases the risk of HD, whereas they suggest that the risk of hepatocellular carcinoma may also be enhanced by HIV infection. The observation of an elevated risk of lung cancer in both HIV-positive and HIV-negative IDU points to personal behaviours unrelated to HIV infection. (C) 2000 Lippincott Williams and Wilkins.
AB - Objective: To evaluate the cancer risk in southern European men with, or at risk of, HIV infection. Design: An analysis of longitudinal data to assess time-dependent rare events. Methods: Data from a cohort of HIV seroconverters, and from two hospital-based HIV seroprevalent cohorts were combined and analysed. The number of cancer cases observed was compared with the expected number, obtained from cancer incidence rates among men in the general population. Age-standardized incidence ratios (SIR) and their 95% confidence intervals (CI) were computed. Results: A total of 19,609 person-years of observation were accumulated among HIV-positive men, and 7957 person-years among HIV-negative men. Among HIV-positive men, statistically significant increased SIR were seen for Hodgkin's disease (HD) (SIR = 8.7), liver cancer (SIR = 11.0), and cancer of the salivary glands (SIR = 33.6). An excess of lung cancer was seen among intravenous drug users (IDU), but not among homosexual men. When the risk of all non-AIDS-defining cancers was considered, HIV-positive men had a nearly twofold excess (95% CI: 1.2-2.8). A risk of similar magnitude emerged among HIV-negative IDU (95% CI: 1.0-4.5), largely attributable to lung cancer and HD. Conclusion: These findings confirm that HIV infection increases the risk of HD, whereas they suggest that the risk of hepatocellular carcinoma may also be enhanced by HIV infection. The observation of an elevated risk of lung cancer in both HIV-positive and HIV-negative IDU points to personal behaviours unrelated to HIV infection. (C) 2000 Lippincott Williams and Wilkins.
KW - Cancers
KW - Cohort study
KW - Drug users
KW - France
KW - HIV
KW - Italy
UR - http://www.scopus.com/inward/record.url?scp=0034128301&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034128301&partnerID=8YFLogxK
U2 - 10.1097/00002030-200003310-00011
DO - 10.1097/00002030-200003310-00011
M3 - Article
C2 - 10780718
AN - SCOPUS:0034128301
VL - 14
SP - 553
EP - 559
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 5
ER -