Cancer risk among men with, or at risk of, HIV infection in southern Europe

Diego Serraino, Antonio Boschini, Patrizia Carrieri, Christian Pradier, Maria Dorrucci, Luigino Dal Maso, Paolo Ballarini, Patrizio Pezzotti, Camillo Smacchia, Alain Pesce, Giuseppe Ippolito, Silvia Franceschi, Giovanni Rezza

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the cancer risk in southern European men with, or at risk of, HIV infection. Design: An analysis of longitudinal data to assess time-dependent rare events. Methods: Data from a cohort of HIV seroconverters, and from two hospital-based HIV seroprevalent cohorts were combined and analysed. The number of cancer cases observed was compared with the expected number, obtained from cancer incidence rates among men in the general population. Age-standardized incidence ratios (SIR) and their 95% confidence intervals (CI) were computed. Results: A total of 19,609 person-years of observation were accumulated among HIV-positive men, and 7957 person-years among HIV-negative men. Among HIV-positive men, statistically significant increased SIR were seen for Hodgkin's disease (HD) (SIR = 8.7), liver cancer (SIR = 11.0), and cancer of the salivary glands (SIR = 33.6). An excess of lung cancer was seen among intravenous drug users (IDU), but not among homosexual men. When the risk of all non-AIDS-defining cancers was considered, HIV-positive men had a nearly twofold excess (95% CI: 1.2-2.8). A risk of similar magnitude emerged among HIV-negative IDU (95% CI: 1.0-4.5), largely attributable to lung cancer and HD. Conclusion: These findings confirm that HIV infection increases the risk of HD, whereas they suggest that the risk of hepatocellular carcinoma may also be enhanced by HIV infection. The observation of an elevated risk of lung cancer in both HIV-positive and HIV-negative IDU points to personal behaviours unrelated to HIV infection. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)553-559
Number of pages7
JournalAIDS (London, England)
Volume14
Issue number5
DOIs
Publication statusPublished - 2000

Fingerprint

HIV Infections
HIV
Neoplasms
Incidence
Drug Users
Hodgkin Disease
Lung Neoplasms
Confidence Intervals
Salivary Gland Neoplasms
Observation
Liver Neoplasms
Lung Diseases
Hepatocellular Carcinoma
Population

Keywords

  • Cancers
  • Cohort study
  • Drug users
  • France
  • HIV
  • Italy

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Cancer risk among men with, or at risk of, HIV infection in southern Europe. / Serraino, Diego; Boschini, Antonio; Carrieri, Patrizia; Pradier, Christian; Dorrucci, Maria; Dal Maso, Luigino; Ballarini, Paolo; Pezzotti, Patrizio; Smacchia, Camillo; Pesce, Alain; Ippolito, Giuseppe; Franceschi, Silvia; Rezza, Giovanni.

In: AIDS (London, England), Vol. 14, No. 5, 2000, p. 553-559.

Research output: Contribution to journalArticle

Serraino, D, Boschini, A, Carrieri, P, Pradier, C, Dorrucci, M, Dal Maso, L, Ballarini, P, Pezzotti, P, Smacchia, C, Pesce, A, Ippolito, G, Franceschi, S & Rezza, G 2000, 'Cancer risk among men with, or at risk of, HIV infection in southern Europe', AIDS (London, England), vol. 14, no. 5, pp. 553-559. https://doi.org/10.1097/00002030-200003310-00011
Serraino, Diego ; Boschini, Antonio ; Carrieri, Patrizia ; Pradier, Christian ; Dorrucci, Maria ; Dal Maso, Luigino ; Ballarini, Paolo ; Pezzotti, Patrizio ; Smacchia, Camillo ; Pesce, Alain ; Ippolito, Giuseppe ; Franceschi, Silvia ; Rezza, Giovanni. / Cancer risk among men with, or at risk of, HIV infection in southern Europe. In: AIDS (London, England). 2000 ; Vol. 14, No. 5. pp. 553-559.
@article{f1a303322f204da4bd4d3955747310af,
title = "Cancer risk among men with, or at risk of, HIV infection in southern Europe",
abstract = "Objective: To evaluate the cancer risk in southern European men with, or at risk of, HIV infection. Design: An analysis of longitudinal data to assess time-dependent rare events. Methods: Data from a cohort of HIV seroconverters, and from two hospital-based HIV seroprevalent cohorts were combined and analysed. The number of cancer cases observed was compared with the expected number, obtained from cancer incidence rates among men in the general population. Age-standardized incidence ratios (SIR) and their 95{\%} confidence intervals (CI) were computed. Results: A total of 19,609 person-years of observation were accumulated among HIV-positive men, and 7957 person-years among HIV-negative men. Among HIV-positive men, statistically significant increased SIR were seen for Hodgkin's disease (HD) (SIR = 8.7), liver cancer (SIR = 11.0), and cancer of the salivary glands (SIR = 33.6). An excess of lung cancer was seen among intravenous drug users (IDU), but not among homosexual men. When the risk of all non-AIDS-defining cancers was considered, HIV-positive men had a nearly twofold excess (95{\%} CI: 1.2-2.8). A risk of similar magnitude emerged among HIV-negative IDU (95{\%} CI: 1.0-4.5), largely attributable to lung cancer and HD. Conclusion: These findings confirm that HIV infection increases the risk of HD, whereas they suggest that the risk of hepatocellular carcinoma may also be enhanced by HIV infection. The observation of an elevated risk of lung cancer in both HIV-positive and HIV-negative IDU points to personal behaviours unrelated to HIV infection. (C) 2000 Lippincott Williams and Wilkins.",
keywords = "Cancers, Cohort study, Drug users, France, HIV, Italy",
author = "Diego Serraino and Antonio Boschini and Patrizia Carrieri and Christian Pradier and Maria Dorrucci and {Dal Maso}, Luigino and Paolo Ballarini and Patrizio Pezzotti and Camillo Smacchia and Alain Pesce and Giuseppe Ippolito and Silvia Franceschi and Giovanni Rezza",
year = "2000",
doi = "10.1097/00002030-200003310-00011",
language = "English",
volume = "14",
pages = "553--559",
journal = "AIDS",
issn = "0269-9370",
publisher = "NLM (Medline)",
number = "5",

}

TY - JOUR

T1 - Cancer risk among men with, or at risk of, HIV infection in southern Europe

AU - Serraino, Diego

AU - Boschini, Antonio

AU - Carrieri, Patrizia

AU - Pradier, Christian

AU - Dorrucci, Maria

AU - Dal Maso, Luigino

AU - Ballarini, Paolo

AU - Pezzotti, Patrizio

AU - Smacchia, Camillo

AU - Pesce, Alain

AU - Ippolito, Giuseppe

AU - Franceschi, Silvia

AU - Rezza, Giovanni

PY - 2000

Y1 - 2000

N2 - Objective: To evaluate the cancer risk in southern European men with, or at risk of, HIV infection. Design: An analysis of longitudinal data to assess time-dependent rare events. Methods: Data from a cohort of HIV seroconverters, and from two hospital-based HIV seroprevalent cohorts were combined and analysed. The number of cancer cases observed was compared with the expected number, obtained from cancer incidence rates among men in the general population. Age-standardized incidence ratios (SIR) and their 95% confidence intervals (CI) were computed. Results: A total of 19,609 person-years of observation were accumulated among HIV-positive men, and 7957 person-years among HIV-negative men. Among HIV-positive men, statistically significant increased SIR were seen for Hodgkin's disease (HD) (SIR = 8.7), liver cancer (SIR = 11.0), and cancer of the salivary glands (SIR = 33.6). An excess of lung cancer was seen among intravenous drug users (IDU), but not among homosexual men. When the risk of all non-AIDS-defining cancers was considered, HIV-positive men had a nearly twofold excess (95% CI: 1.2-2.8). A risk of similar magnitude emerged among HIV-negative IDU (95% CI: 1.0-4.5), largely attributable to lung cancer and HD. Conclusion: These findings confirm that HIV infection increases the risk of HD, whereas they suggest that the risk of hepatocellular carcinoma may also be enhanced by HIV infection. The observation of an elevated risk of lung cancer in both HIV-positive and HIV-negative IDU points to personal behaviours unrelated to HIV infection. (C) 2000 Lippincott Williams and Wilkins.

AB - Objective: To evaluate the cancer risk in southern European men with, or at risk of, HIV infection. Design: An analysis of longitudinal data to assess time-dependent rare events. Methods: Data from a cohort of HIV seroconverters, and from two hospital-based HIV seroprevalent cohorts were combined and analysed. The number of cancer cases observed was compared with the expected number, obtained from cancer incidence rates among men in the general population. Age-standardized incidence ratios (SIR) and their 95% confidence intervals (CI) were computed. Results: A total of 19,609 person-years of observation were accumulated among HIV-positive men, and 7957 person-years among HIV-negative men. Among HIV-positive men, statistically significant increased SIR were seen for Hodgkin's disease (HD) (SIR = 8.7), liver cancer (SIR = 11.0), and cancer of the salivary glands (SIR = 33.6). An excess of lung cancer was seen among intravenous drug users (IDU), but not among homosexual men. When the risk of all non-AIDS-defining cancers was considered, HIV-positive men had a nearly twofold excess (95% CI: 1.2-2.8). A risk of similar magnitude emerged among HIV-negative IDU (95% CI: 1.0-4.5), largely attributable to lung cancer and HD. Conclusion: These findings confirm that HIV infection increases the risk of HD, whereas they suggest that the risk of hepatocellular carcinoma may also be enhanced by HIV infection. The observation of an elevated risk of lung cancer in both HIV-positive and HIV-negative IDU points to personal behaviours unrelated to HIV infection. (C) 2000 Lippincott Williams and Wilkins.

KW - Cancers

KW - Cohort study

KW - Drug users

KW - France

KW - HIV

KW - Italy

UR - http://www.scopus.com/inward/record.url?scp=0034128301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034128301&partnerID=8YFLogxK

U2 - 10.1097/00002030-200003310-00011

DO - 10.1097/00002030-200003310-00011

M3 - Article

C2 - 10780718

AN - SCOPUS:0034128301

VL - 14

SP - 553

EP - 559

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 5

ER -