Cancer stem cells: Are they responsible for treatment failure?

Marcello Maugeri-Saccà, Patrizia Vici, Luigi Di Lauro, Maddalena Barba, Carla Azzurra Amoreo, Enzo Gallo, Marcella Mottolese, Ruggero De Maria

Research output: Contribution to journalArticle

Abstract

Overcoming resistance to standard anticancer treatments represents a significant challenge. The interest regarding cancer stem cells, a cellular population that has the ability to self-renew and to propagate the tumor, was prompted by experimental evidence delineating the molecular mechanisms that are selectively activated in this cellular subset in order to survive chemotherapy. This has also stimulated combination strategies aimed at rendering cancer stem cells vulnerable to anticancer agents. Moreover, cancer stem cells offer a unique opportunity for modeling human cancers in mice, thus emerging as a powerful tool for testing novel drugs and combinations in a simulation of human disease. These novel animal models may lay the foundation for a new generation of clinical trials aimed at anticipating the benefit to patients of anticancer therapies.

Original languageEnglish
Pages (from-to)2033-2044
Number of pages12
JournalFuture Oncology
Volume10
Issue number13
DOIs
Publication statusPublished - Oct 1 2014

Keywords

  • Apoptotic pathways
  • Cancer stem cells
  • Chemotherapy
  • Clonal evolution
  • CSC-derived xenografts
  • Differentiation
  • Dna damage repair
  • Hierarchical model
  • Self-renewal pathways
  • Survival pathways

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Medicine(all)

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