Cancer stem cells in prostate adenocarcinoma

Daniela Fioriti, Anna Bellizzi, Franco Di Silverio, Fernanda Chiarini, Valeria Pietropaolo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Prostate cancer is the most frequently diagnosed cancer and it is excelled only by lung cancer as the leading cause of cancer-related mortality among men. Although there has been progress in the detection of early prostate cancer, there are few therapeutic strategies for patients with locally advanced and/or metastatic disease. In fact, most patients with advanced disease respond initially to androgen ablation therapy, however, with very high frequency, androgen-independent cancers emerge and subsequently widespread metastasis occurs. Therefore, actually it is necessary to find new therapeutic strategies for this cancer. The cancer stem cell hypothesis has been receiving considerable attention in various solid tumors and in prostate cancer. According to the stem cell hypothesis a majority of mutations occur in stem cells and heterogeneity results from the ability of mutant stem cells to differentiate, thus the study of prostate cancer stem cells could eventually offer new ways to treat the incurable forms of prostate cancer. Moreover, this improved knowledge will also be a step forward in learning how we might help to prevent the disease from developing in men in the first place. On the basis of the actually knowledge, we describe the "status of art" of stem cell in prostate cancer, focused our attention on markers and methods for identifying stem cells, genetic features of prostate cancer and the relation between stem cells, inflammation and cancer in prostatic tissue.

Original languageEnglish
Title of host publicationStem Cell, Regenerative Medicine and Cancer
PublisherNova Science Publishers, Inc.
Pages667-694
Number of pages28
ISBN (Print)9781617287879
Publication statusPublished - 2011

Fingerprint

Neoplastic Stem Cells
Stem cells
Prostate
Prostatic Neoplasms
Adenocarcinoma
Stem Cells
Neoplasms
Androgens
Aptitude
Art
Ablation
Lung Neoplasms
Therapeutics
Tumors
Learning
Neoplasm Metastasis
Inflammation
Mutation
Tissue
Mortality

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Fioriti, D., Bellizzi, A., Di Silverio, F., Chiarini, F., & Pietropaolo, V. (2011). Cancer stem cells in prostate adenocarcinoma. In Stem Cell, Regenerative Medicine and Cancer (pp. 667-694). Nova Science Publishers, Inc..

Cancer stem cells in prostate adenocarcinoma. / Fioriti, Daniela; Bellizzi, Anna; Di Silverio, Franco; Chiarini, Fernanda; Pietropaolo, Valeria.

Stem Cell, Regenerative Medicine and Cancer. Nova Science Publishers, Inc., 2011. p. 667-694.

Research output: Chapter in Book/Report/Conference proceedingChapter

Fioriti, D, Bellizzi, A, Di Silverio, F, Chiarini, F & Pietropaolo, V 2011, Cancer stem cells in prostate adenocarcinoma. in Stem Cell, Regenerative Medicine and Cancer. Nova Science Publishers, Inc., pp. 667-694.
Fioriti D, Bellizzi A, Di Silverio F, Chiarini F, Pietropaolo V. Cancer stem cells in prostate adenocarcinoma. In Stem Cell, Regenerative Medicine and Cancer. Nova Science Publishers, Inc. 2011. p. 667-694
Fioriti, Daniela ; Bellizzi, Anna ; Di Silverio, Franco ; Chiarini, Fernanda ; Pietropaolo, Valeria. / Cancer stem cells in prostate adenocarcinoma. Stem Cell, Regenerative Medicine and Cancer. Nova Science Publishers, Inc., 2011. pp. 667-694
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