Cancer targeted therapy strategy: The pathologist’s perspectives

Lara Alessandrini, Tiziana Perin, Shahin Kadarè, Lino Del Pup, Lorenzo Memeo, Agostino Steffan, Lorenzo Colarossi, Massimiliano Berretta, Paolo De Paoli, Vincenzo Canzonieri

Research output: Contribution to journalReview article

Abstract

The effectiveness of new personalized treatment procedures in oncology is based on the fact that certain tumors exhibit specific molecular features. More in detail, neoplastic tissues of patients should display a specific biomarker, most often a specific genetic alteration and/or under/overexpression of a definite protein, that could be the target of its respective drug. Immunohistochemical and molecular analyses, which usually include examination of nucleic acids from either tissues or fluids, are common tests to define the status of a tumor. This review focuses on the pathologist’s role in carefully controlling pre-analytic procedures and standard operating procedures that are a crucial prerequisite to reach reliable and reproducible results. Six paradigmatic applications of targeted therapy, for which pathological diagnosis plays a fundamental role, are summarized. Traditional and next-generation sequencing are also addressed from the pathologist’s perspective as well as the importance pathologists have in this shift to more accurate definition of disease risk and prognostication of therapy response in the personalized medicine era.

Original languageEnglish
Pages (from-to)410-420
Number of pages11
JournalCurrent Cancer Drug Targets
Volume18
Issue number5
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Biomarker
  • FFPE tissue
  • Immunohistochemistry
  • Molecular analyses
  • Next-generation sequencing
  • Pathologist’s perspective
  • Target therapy
  • Traditional sequencing
  • Cancer targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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