Cancer testis antigens expression in mesothelioma: Role of DNA methylation and bioimmunotherapeutic implications

L. Sigalotti, S. Coral, M. Altomonte, L. Natali, G. Gaudino, P. Cacciotti, R. Libener, F. Colizzi, G. Vianale, F. Martini, M. Tognon, A. Jungbluth, J. Cebon, E. Maraskovsky, L. Mutti, M. Maio

Research output: Contribution to journalArticle

Abstract

Recent evidences suggest that malignant mesothelioma may be sensitive to immunotherapy; however, little is known about malignant mesothelioma-associated tumour antigens. Focusing on cancer/testis antigens, the expression of well-characterised immunogenic tumour-associated antigens was investigated in malignant mesothelioma cells. At variance with MAGE-4 and NY-ESO-1, malignant mesothelioma cells frequently expressed MAGE-1, -2 and -3, GAGE 1-2, GAGE 1-6, SSX-2 and SSX 1-5, and distinct malignant mesothelioma cells concomitantly expressed at least four cancer/testis antigens. Additionally, the tumour-associated antigens RAGE-1 was expressed at high levels in both benign and malignant mesothelial cells. Lastly, treatment with the DNA hypomethylating agent 5-aza-2′-deoxycytidine induced and up-regulated the expression of the cancer/testis antigen examined in malignant mesothelioma cells. Overall, these findings strongly suggest that cancer/testis antigens-based immunotherapy may represent a suitable therapeutic approach to malignant mesothelioma, and foresee the clinical use of 5-aza-2′-deoxycytidine to design new chemo-immunotherapeutic strategies in malignant mesothelioma patients.

Original languageEnglish
Pages (from-to)979-982
Number of pages4
JournalBritish Journal of Cancer
Volume86
Issue number6
DOIs
Publication statusPublished - Mar 18 2002

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Keywords

  • 5-aza-2′-deoxycytidine
  • Cancer testis antigens
  • Immunotherapy
  • Mesothelioma
  • Methylation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Sigalotti, L., Coral, S., Altomonte, M., Natali, L., Gaudino, G., Cacciotti, P., Libener, R., Colizzi, F., Vianale, G., Martini, F., Tognon, M., Jungbluth, A., Cebon, J., Maraskovsky, E., Mutti, L., & Maio, M. (2002). Cancer testis antigens expression in mesothelioma: Role of DNA methylation and bioimmunotherapeutic implications. British Journal of Cancer, 86(6), 979-982. https://doi.org/10.1038/sj.bjc.6600174