Cancer treatment-induced oral mucositis

Research output: Contribution to journalArticle

Abstract

Oral mucositis is one of the main complications in non-surgical cancer treatments. It represents the major dose-limiting toxicity for some chemotherapeutic agents, for radiotherapy of the head and neck region and for some radiochemotherapy combined treatments. Many reviews and clinical studies have been published in order to define the best clinical protocol for prophylaxis or treatment of mucositis, but a consensus has not yet been obtained. This paper represents an updated review of prophylaxis and treatment of antineoplastic-therapy-related mucositis using a MEDLINE search up to May 2006, in which more than 260 clinical studies have been found. They have been divided according to antineoplastic therapy (chemotherapy, radiotherapy, chemo-radiotherapy, high-dose chemotherapy). The prophylactic or therapeutic use of the analysed agents, the number of enrolled patients and the study design (randomized or not) were also specified for most studies. Accurate pre-treatment assessment of oral cavity hygiene, frequent review of symptoms during treatment, use of traditional mouthwashes to obtain mechanical cleaning of the oral cavity and administration of some agents like benzydamine, imidazole antibiotics, tryazolic antimycotics, povidone iodine, keratinocyte growth factor and vitamin E seem to reduce the intensity of mucositis. Physical approaches like cryotherapy, low energy Helium-Neon laser or the use of modern radiotherapy techniques with the exclusion of the oral cavity from radiation fields have been shown to be efficacious in preventing mucositis onset. Nevertheless a consensus protocol of prophylaxis and treatment of oral mucositis has not yet been obtained.

Original languageEnglish
Pages (from-to)1105-1125
Number of pages21
JournalAnticancer Research
Volume27
Issue number2
Publication statusPublished - Mar 2007

Fingerprint

Stomatitis
Mucositis
Neoplasms
Radiotherapy
Mouth
Therapeutics
Clinical Protocols
Antineoplastic Agents
Benzydamine
Neon
Mouthwashes
Fibroblast Growth Factor 7
Povidone-Iodine
Drug Therapy
Cryotherapy
Gas Lasers
Oral Hygiene
Chemoradiotherapy
Therapeutic Uses
Vitamin E

Keywords

  • Cancer
  • Chemotherapy
  • Mucositis
  • Radiotherapy
  • Review

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cancer treatment-induced oral mucositis. / Alterio, Daniela; Jereczek-Fossa, Barbara Alicja; Fiore, Maria Rosaria; Piperno, Gaia; Ansarin, Mohssen; Orecchia, Roberto.

In: Anticancer Research, Vol. 27, No. 2, 03.2007, p. 1105-1125.

Research output: Contribution to journalArticle

@article{e825c7443fa04ae7a44ca6cabb63a7ce,
title = "Cancer treatment-induced oral mucositis",
abstract = "Oral mucositis is one of the main complications in non-surgical cancer treatments. It represents the major dose-limiting toxicity for some chemotherapeutic agents, for radiotherapy of the head and neck region and for some radiochemotherapy combined treatments. Many reviews and clinical studies have been published in order to define the best clinical protocol for prophylaxis or treatment of mucositis, but a consensus has not yet been obtained. This paper represents an updated review of prophylaxis and treatment of antineoplastic-therapy-related mucositis using a MEDLINE search up to May 2006, in which more than 260 clinical studies have been found. They have been divided according to antineoplastic therapy (chemotherapy, radiotherapy, chemo-radiotherapy, high-dose chemotherapy). The prophylactic or therapeutic use of the analysed agents, the number of enrolled patients and the study design (randomized or not) were also specified for most studies. Accurate pre-treatment assessment of oral cavity hygiene, frequent review of symptoms during treatment, use of traditional mouthwashes to obtain mechanical cleaning of the oral cavity and administration of some agents like benzydamine, imidazole antibiotics, tryazolic antimycotics, povidone iodine, keratinocyte growth factor and vitamin E seem to reduce the intensity of mucositis. Physical approaches like cryotherapy, low energy Helium-Neon laser or the use of modern radiotherapy techniques with the exclusion of the oral cavity from radiation fields have been shown to be efficacious in preventing mucositis onset. Nevertheless a consensus protocol of prophylaxis and treatment of oral mucositis has not yet been obtained.",
keywords = "Cancer, Chemotherapy, Mucositis, Radiotherapy, Review",
author = "Daniela Alterio and Jereczek-Fossa, {Barbara Alicja} and Fiore, {Maria Rosaria} and Gaia Piperno and Mohssen Ansarin and Roberto Orecchia",
year = "2007",
month = "3",
language = "English",
volume = "27",
pages = "1105--1125",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "2",

}

TY - JOUR

T1 - Cancer treatment-induced oral mucositis

AU - Alterio, Daniela

AU - Jereczek-Fossa, Barbara Alicja

AU - Fiore, Maria Rosaria

AU - Piperno, Gaia

AU - Ansarin, Mohssen

AU - Orecchia, Roberto

PY - 2007/3

Y1 - 2007/3

N2 - Oral mucositis is one of the main complications in non-surgical cancer treatments. It represents the major dose-limiting toxicity for some chemotherapeutic agents, for radiotherapy of the head and neck region and for some radiochemotherapy combined treatments. Many reviews and clinical studies have been published in order to define the best clinical protocol for prophylaxis or treatment of mucositis, but a consensus has not yet been obtained. This paper represents an updated review of prophylaxis and treatment of antineoplastic-therapy-related mucositis using a MEDLINE search up to May 2006, in which more than 260 clinical studies have been found. They have been divided according to antineoplastic therapy (chemotherapy, radiotherapy, chemo-radiotherapy, high-dose chemotherapy). The prophylactic or therapeutic use of the analysed agents, the number of enrolled patients and the study design (randomized or not) were also specified for most studies. Accurate pre-treatment assessment of oral cavity hygiene, frequent review of symptoms during treatment, use of traditional mouthwashes to obtain mechanical cleaning of the oral cavity and administration of some agents like benzydamine, imidazole antibiotics, tryazolic antimycotics, povidone iodine, keratinocyte growth factor and vitamin E seem to reduce the intensity of mucositis. Physical approaches like cryotherapy, low energy Helium-Neon laser or the use of modern radiotherapy techniques with the exclusion of the oral cavity from radiation fields have been shown to be efficacious in preventing mucositis onset. Nevertheless a consensus protocol of prophylaxis and treatment of oral mucositis has not yet been obtained.

AB - Oral mucositis is one of the main complications in non-surgical cancer treatments. It represents the major dose-limiting toxicity for some chemotherapeutic agents, for radiotherapy of the head and neck region and for some radiochemotherapy combined treatments. Many reviews and clinical studies have been published in order to define the best clinical protocol for prophylaxis or treatment of mucositis, but a consensus has not yet been obtained. This paper represents an updated review of prophylaxis and treatment of antineoplastic-therapy-related mucositis using a MEDLINE search up to May 2006, in which more than 260 clinical studies have been found. They have been divided according to antineoplastic therapy (chemotherapy, radiotherapy, chemo-radiotherapy, high-dose chemotherapy). The prophylactic or therapeutic use of the analysed agents, the number of enrolled patients and the study design (randomized or not) were also specified for most studies. Accurate pre-treatment assessment of oral cavity hygiene, frequent review of symptoms during treatment, use of traditional mouthwashes to obtain mechanical cleaning of the oral cavity and administration of some agents like benzydamine, imidazole antibiotics, tryazolic antimycotics, povidone iodine, keratinocyte growth factor and vitamin E seem to reduce the intensity of mucositis. Physical approaches like cryotherapy, low energy Helium-Neon laser or the use of modern radiotherapy techniques with the exclusion of the oral cavity from radiation fields have been shown to be efficacious in preventing mucositis onset. Nevertheless a consensus protocol of prophylaxis and treatment of oral mucositis has not yet been obtained.

KW - Cancer

KW - Chemotherapy

KW - Mucositis

KW - Radiotherapy

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=34247146542&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247146542&partnerID=8YFLogxK

M3 - Article

C2 - 17465250

AN - SCOPUS:34247146542

VL - 27

SP - 1105

EP - 1125

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 2

ER -