Cancer vaccination by electro-gene-transfer

Luigi Aurisicchio, Rita Mancini, Gennaro Ciliberto

Research output: Contribution to journalArticle

Abstract

Therapeutic vaccination could become an important modality to fight cancer. Efficacious immune responses against cancer cells have to be directed simultaneously against multiple epitopes belonging to tumor-associated antigens and will require the involvement of both CD4+ and CD8+ cells as well as antibodies. The inoculation of a nucleic acid coding for a protein antigen by means of intradermal or intramuscular injection is a simple and cheap approach to induce an immune response against a target antigen. For long time, however, clinical translation of this concept has suffered from the poor immunogenicity of plasmid DNA vaccines in larger species. An emerging technology potentially capable of overcoming these limitations is in vivo electroporation. In this review, we report recent data showing initial evidence of immunogenicity by gene-electro-transfer in the clinic and discuss how new vector development combined with in vivo electroporation will allow nucleic acid vaccination to become a robust approach to fight cancer.

Original languageEnglish
Pages (from-to)1127-1137
Number of pages11
JournalExpert Review of Vaccines
Volume12
Issue number10
DOIs
Publication statusPublished - 2013

Fingerprint

Vaccination
Electroporation
Nucleic Acids
Genes
Antigens
Intradermal Injections
Neoplasms
DNA Vaccines
Intramuscular Injections
Neoplasm Antigens
Epitopes
Plasmids
Technology
Antibodies
Proteins
Therapeutics

Keywords

  • clinical trials
  • DNA and RNA vaccines ogeneticvaccination
  • immunotherapy of cancer
  • in vivo electroporation

ASJC Scopus subject areas

  • Immunology
  • Drug Discovery
  • Pharmacology
  • Molecular Medicine

Cite this

Cancer vaccination by electro-gene-transfer. / Aurisicchio, Luigi; Mancini, Rita; Ciliberto, Gennaro.

In: Expert Review of Vaccines, Vol. 12, No. 10, 2013, p. 1127-1137.

Research output: Contribution to journalArticle

Aurisicchio, Luigi ; Mancini, Rita ; Ciliberto, Gennaro. / Cancer vaccination by electro-gene-transfer. In: Expert Review of Vaccines. 2013 ; Vol. 12, No. 10. pp. 1127-1137.
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