TY - JOUR
T1 - Cancer vaccine development
T2 - On the way to break immune tolerance to malignant cells
AU - Mocellin, Simone
AU - Rossi, Carlo Riccardo
AU - Nitti, Donato
PY - 2004/10/1
Y1 - 2004/10/1
N2 - Exploiting a naturally occurring defense system, the immunotherapeutic approach embodies an ideal nontoxic treatment for cancer. Despite the evidence that immune effectors can play a significant role in controlling tumor growth either in natural conditions or in response to therapeutic manipulation, the cascade of molecular events leading to tumor rejection by the immune system remains to be fully elucidated. Nevertheless, some recent tumor immunology advancements might drastically change the way to design the next generation of cancer vaccines, hopefully improving the effectiveness of this therapeutic approach. In the present work, we will focus on three main areas of particular interest for the development of novel vaccination strategies: (a) cellular or molecular mechanisms of immune tolerance to malignant cells; (b) synergism between innate and adaptive immune response; (c) tumor-immune system interactions within the tumor microenvironment.
AB - Exploiting a naturally occurring defense system, the immunotherapeutic approach embodies an ideal nontoxic treatment for cancer. Despite the evidence that immune effectors can play a significant role in controlling tumor growth either in natural conditions or in response to therapeutic manipulation, the cascade of molecular events leading to tumor rejection by the immune system remains to be fully elucidated. Nevertheless, some recent tumor immunology advancements might drastically change the way to design the next generation of cancer vaccines, hopefully improving the effectiveness of this therapeutic approach. In the present work, we will focus on three main areas of particular interest for the development of novel vaccination strategies: (a) cellular or molecular mechanisms of immune tolerance to malignant cells; (b) synergism between innate and adaptive immune response; (c) tumor-immune system interactions within the tumor microenvironment.
KW - Cancer
KW - Immune tolerance
KW - Vaccine development
UR - http://www.scopus.com/inward/record.url?scp=4444329501&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4444329501&partnerID=8YFLogxK
U2 - 10.1016/j.yexcr.2004.06.017
DO - 10.1016/j.yexcr.2004.06.017
M3 - Article
C2 - 15350526
AN - SCOPUS:4444329501
VL - 299
SP - 267
EP - 278
JO - Experimental Cell Research
JF - Experimental Cell Research
SN - 0014-4827
IS - 2
ER -