CancerGeneNet: linking driver genes to cancer hallmarks

Marta Iannuccelli, Elisa Micarelli, Prisca Lo Surdo, Alessandro Palma, Livia Perfetto, Ilaria Rozzo, Luisa Castagnoli, Luana Licata, Gianni Cesareni

Research output: Contribution to journalArticle

Abstract

CancerGeneNet (https://signor.uniroma2.it/CancerGeneNet/) is a resource that links genes that are frequently mutated in cancers to cancer phenotypes. The resource takes advantage of a curation effort aimed at embedding a large fraction of the gene products that are found altered in cancer cells into a network of causal protein relationships. Graph algorithms, in turn, allow to infer likely paths of causal interactions linking cancer associated genes to cancer phenotypes thus offering a rational framework for the design of strategies to revert disease phenotypes. CancerGeneNet bridges two interaction layers by connecting proteins whose activities are affected by cancer drivers to proteins that impact on the 'hallmarks of cancer'. In addition, CancerGeneNet annotates curated pathways that are relevant to rationalize the pathological consequences of cancer driver mutations in selected common cancers and 'MiniPathways' illustrating regulatory circuits that are frequently altered in different cancers.

Original languageEnglish
Pages (from-to)D416-D421
JournalNucleic Acids Research
Volume48
Issue numberD1
DOIs
Publication statusE-pub ahead of print - Oct 10 2019

ASJC Scopus subject areas

  • Genetics

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  • Cite this

    Iannuccelli, M., Micarelli, E., Surdo, P. L., Palma, A., Perfetto, L., Rozzo, I., Castagnoli, L., Licata, L., & Cesareni, G. (2019). CancerGeneNet: linking driver genes to cancer hallmarks. Nucleic Acids Research, 48(D1), D416-D421. https://doi.org/10.1093/nar/gkz871