Candida albicans cellular internalization: A new pathogenic factor?

Lorenzo Drago, Barbara Mombelli, Elena De Vecchi, Carmen Bonaccorso, Maria Cristina Fassina, Maria Rita Gismondo

Research output: Contribution to journalArticlepeer-review


The preliminary results of a study to show the possibility that Candida albicans can internalize into epithelial cells are reported. The study was performed on buccal, vaginal and HeLa cells. Buccal and vaginal cells, at a concentration of 5 x 10 4 cells/ml and HeLa monolayers were incubated for 2, 3 and 4 h with 10 5 colony forming units of a Candida albicans isolate. After incubation, non-internalised yeasts were eliminated and samples were processed for examination by Scanning Electron Microscopy. Results suggest that receptor-mediated endocytosis could be involved in the pathogenesis of recurrent oral and vaginal infections. This phenomenon could represent an interesting experimental model to testing drug interference in the development of therapeutic strategies against C. albicans infections. (C) 2000 Elsevier Science B.V. and International Society of Chemotherapy.

Original languageEnglish
Pages (from-to)545-547
Number of pages3
JournalInternational Journal of Antimicrobial Agents
Issue number4
Publication statusPublished - 2000


  • Candida albicans
  • Cellular internalization
  • Pathogenic factors

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases


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