Candida albicans in a neonatal intensive care unit: Antifungal susceptibility and genotypic analysis

Sara Asticcioli, Elisabetta Nucleo, Gianfranco Perotti, Cecilia Matti, Laura Sacco, Laura Pagani

Research output: Contribution to journalArticle

Abstract

Invasive candidiasis in neonates has become an increasing problem over the past decade in Neonatal Intensive Care Units (NICUs). From August 2005 to January 2006, six invasive candidiasis occurred in neonates in NICU of the S. Matteo hospital of Pavia. The study focused on the species involved and their in vitro antifungal susceptibility. Genotyping was conducted to determine clonal relatedness. A total of 22 yeasts were isolated from different biological samples of neonates during six months. The infants were infected with or colonized by Candida albicans and six patients developed C. albicans deep infections. The genotyping of the transposable intron region of C. albicans strains showed that they belonged to the genotype A (17 isolates) and genotype B (5 isolates). The RAPD confirmed these results. These data suggest that nosocomial transmission of C. albicans could be take into account as a mode of acquisition by neonates in NICUs at this hospital.

Original languageEnglish
Pages (from-to)303-307
Number of pages5
JournalNew Microbiologica
Volume30
Issue number3
Publication statusPublished - Jul 2007

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Neonatal Intensive Care Units
Candida albicans
Invasive Candidiasis
Newborn Infant
Genotype
Introns
Yeasts
Infection

Keywords

  • Candida albicans
  • Genotyping
  • NICU

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Candida albicans in a neonatal intensive care unit : Antifungal susceptibility and genotypic analysis. / Asticcioli, Sara; Nucleo, Elisabetta; Perotti, Gianfranco; Matti, Cecilia; Sacco, Laura; Pagani, Laura.

In: New Microbiologica, Vol. 30, No. 3, 07.2007, p. 303-307.

Research output: Contribution to journalArticle

Asticcioli, Sara ; Nucleo, Elisabetta ; Perotti, Gianfranco ; Matti, Cecilia ; Sacco, Laura ; Pagani, Laura. / Candida albicans in a neonatal intensive care unit : Antifungal susceptibility and genotypic analysis. In: New Microbiologica. 2007 ; Vol. 30, No. 3. pp. 303-307.
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