Candida infections in the intensive care unit: Epidemiology, risk factors and therapeutic strategies

Matteo Bassetti, Elda Righi, Mario Tumbarello, Antonio Di Biagio, Raffaella Rosso, Claudio Viscoli

Research output: Contribution to journalArticle

Abstract

This article reviews the epidemiology, predisposing risk factors and outcome of systemic Candida spp. infections in the intensive care unit setting. Incidence of systemic Candida infections in patients requiring intensive care has increased substantially in recent years; while diagnosis of serious Candida infection may be difficult, the clinical conditions which predispose patients to these infections are now better understood and effective antifungal therapies are becoming increasingly available. Severe fungal infections are generally associated with poor outcomes in these patients. Patients at highest risk for Candida infection may be potential candidates for early, presumptive therapy. In this article we review antifungal treatment, including the use of polyenes, azoles and echinocandines, and the role of prophylaxis.

Original languageEnglish
Pages (from-to)875-885
Number of pages11
JournalExpert Review of Anti-Infective Therapy
Volume4
Issue number5
DOIs
Publication statusPublished - Oct 2006

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Keywords

  • Antifungal therapy
  • Candidemia
  • Intensive care unit
  • Risk factors

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

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