Candida infective endocarditis: Report of 15 cases from a prospective multicenter study

Marco Falcone, Nicoletta Barzaghi, Giampiero Carosi, Paolo Grossi, Lorenzo Minoli, Veronica Ravasio, Marco Rizzi, Fredy Suter, Riccardo Utili, Claudio Viscoli, Mario Venditti

Research output: Contribution to journalArticlepeer-review

Abstract

Candida species are an uncommon cause of infective endocarditis (IE). Given the rarity of this infection, the epidemiology, prognosis, and optimal therapy of Candida IE are poorly defined. We conducted a prospective, observational study at 18 medical centers in Italy, including all consecutive patients with a definite diagnosis of IE admitted from January 2004 through December 2007.A Candida species was the causative organism in 8 cases of prosthetic valve endocarditis (PVE), 5 cases of native valve endocarditis (NVE), 1 case of pacemaker endocarditis, and 1 case of left ventricular patch infection. Candida species accounted for 1.8% of total cases, and for 3.4% of PVE cases. Most patients (86.6%) had a health care-associated infection. PVE associated with a health care contact occurred after a median of 225 days from valve implantation. Ten patients (66.6%) were treated with caspofungin alone or in combination with other antifungal drugs. The overall mortality rate was 46.6%. Mortality was higher in patients with PVE (5 of 8 cases, 62.5%) than in patients with NVE (2 of 5 patients, 40%). A better outcome was observed in patients treated with a combined medical and surgical therapy.Candida IE should be classified as an emerging infectious disease, usually involving patients with intravascular prosthetic devices, and associated with substantial related morbidity and mortality. Candida PVE usually is a late-onset disease, which becomes clinically evident even several months after an initial episode of transient candidemia.

Original languageEnglish
Pages (from-to)160-168
Number of pages9
JournalMedicine
Volume88
Issue number3
DOIs
Publication statusPublished - May 2009

ASJC Scopus subject areas

  • Medicine(all)

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