Candida overgrowth in gastric juice of peptic ulcer subjects on short- and long-term treatment with h2-receptor antagonists

M. Boero, A. Pera, A. Andriulli, V. Ponti, G. Canepa, F. Palmas, A. Duglio, G. C. Molinaro, M. Toselli, N. Riccardino

Research output: Contribution to journalArticlepeer-review

Abstract

Candida overgrowth in gastric juice of peptic ulcer subjects under therapy with H2-receptor (H2-R) antagonists has been detected in 21.4 and 53.8% of cases after short- and long-term treatment respectively, and in 8 % of controls. Both types of H2-R antagonists, ranitidine and cimetidine, were equally associated with production of yeasts. The location of ulcers, whether gastric or duodenal, seems to have no influence on fungal growth. Females were more susceptible than males to develop Candida in gastric juice. In the short-term course with H2-R blockers fungal colonization of gastric juice was associated with delay of the rate of ulcer healing. Fungal detection in gastric juice was not associated with mucosal invasion by Candida since in none of the patients who had a biopsy for gastric ulcer was Candida detected by histology.

Original languageEnglish
Pages (from-to)158-163
Number of pages6
JournalDigestion
Volume28
Issue number3
DOIs
Publication statusPublished - 1983

Keywords

  • Candida
  • Cimetidine
  • Gastric juice
  • H<inf>2</inf>-receptor antagonists
  • Peptic ulcer

ASJC Scopus subject areas

  • Gastroenterology

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