Candidemia in non-ICU surgical wards

Comparison with medical wards

Antonio Vena, Emilio Bouza, Maricela Valerio, Belén Padilla, José Ramón Paño-Pardo, Mario Fernández-Ruiz, Ana Díaz Martín, Miguel Salavert, Alessandra Mularoni, Mireia Puig-Asensio, Patricia Muñoz, CANDIPOP Project

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Candidemia acquired outside critical care or hematological areas has received much attention in recent years; however, data on candidemia in surgical departments are very scarce. Our objectives were to describe episodes of candidemia diagnosed in surgical wards and to compare them with episodes occurring in medical wards. We performed a post hoc analysis of a prospective, multicenter study implemented in Spain during 2010–2011 (CANDIPOP project). Of the 752 episodes of candidemia, 369 (49.1%) occurred in patients admitted to surgical wards (165, 21.9%) or medical wards (204, 27.2%). Clinical characteristics associated with surgical patients were solid tumor as underlying disease, recent surgery, indwelling CVC, and parenteral nutrition. Candidemia was more commonly related to a CVC in the surgical than in the medical wards. The CVC was removed more frequently and early management was more appropriate within 48 hours of blood sampling in the surgical patients. Overall, 30-day mortality in the surgical departments was significantly lower than in medical wards (37.7% vs. 15.8%, p<0.001). Multivariate analysis revealed admission to a surgical ward and appropriate early management of candidemia as factors independently associated with a better outcome. We found that approximately 50% of episodes of candidemia occurred in non-hematological patients outside the ICU and that clinical outcome was better in patients admitted to surgical wards than in those hospitalized in medical wards. These findings can be explained by the lower severity of underlying disease, prompt administration of antifungal therapy, and central venous catheter removal.

Original languageEnglish
Article numbere0185339
JournalPLoS One
Volume12
Issue number10
DOIs
Publication statusPublished - Oct 18 2017

Fingerprint

Candidemia
Intensive care units
Catheters
Nutrition
Surgery
Tumors
Blood
Sampling
blood sampling
parenteral feeding
prospective studies
catheters
disease severity
multivariate analysis
Central Venous Catheters
Parenteral Nutrition
surgery
Critical Care
Spain
Multicenter Studies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Vena, A., Bouza, E., Valerio, M., Padilla, B., Paño-Pardo, J. R., Fernández-Ruiz, M., ... CANDIPOP Project (2017). Candidemia in non-ICU surgical wards: Comparison with medical wards. PLoS One, 12(10), [e0185339]. https://doi.org/10.1371/journal.pone.0185339

Candidemia in non-ICU surgical wards : Comparison with medical wards. / Vena, Antonio; Bouza, Emilio; Valerio, Maricela; Padilla, Belén; Paño-Pardo, José Ramón; Fernández-Ruiz, Mario; Martín, Ana Díaz; Salavert, Miguel; Mularoni, Alessandra; Puig-Asensio, Mireia; Muñoz, Patricia; CANDIPOP Project.

In: PLoS One, Vol. 12, No. 10, e0185339, 18.10.2017.

Research output: Contribution to journalArticle

Vena, A, Bouza, E, Valerio, M, Padilla, B, Paño-Pardo, JR, Fernández-Ruiz, M, Martín, AD, Salavert, M, Mularoni, A, Puig-Asensio, M, Muñoz, P & CANDIPOP Project 2017, 'Candidemia in non-ICU surgical wards: Comparison with medical wards', PLoS One, vol. 12, no. 10, e0185339. https://doi.org/10.1371/journal.pone.0185339
Vena A, Bouza E, Valerio M, Padilla B, Paño-Pardo JR, Fernández-Ruiz M et al. Candidemia in non-ICU surgical wards: Comparison with medical wards. PLoS One. 2017 Oct 18;12(10). e0185339. https://doi.org/10.1371/journal.pone.0185339
Vena, Antonio ; Bouza, Emilio ; Valerio, Maricela ; Padilla, Belén ; Paño-Pardo, José Ramón ; Fernández-Ruiz, Mario ; Martín, Ana Díaz ; Salavert, Miguel ; Mularoni, Alessandra ; Puig-Asensio, Mireia ; Muñoz, Patricia ; CANDIPOP Project. / Candidemia in non-ICU surgical wards : Comparison with medical wards. In: PLoS One. 2017 ; Vol. 12, No. 10.
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