Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common μ1 opioid receptor mechanism

Gianluigi Tanda, Francesco E. Pontieri, Gaetano Di Chiara

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of the active ingredient of Cannabis, Δ- tetrahydrocannabinol (Δ9-THC), and of the highly addictive drug heroin on in vivo dopamine transmission in the nucleus accumbens were compared in Sprague-Dawley rats by brain microdialysis. Δ9-THC and heroin increased extracellular dopamine concentrations selectively in the shell of the nucleus accumbens; these effects were mimicked by the synthetic cannabinoid agonist WIN55212-2. SR141716A, an antagonist of central cannabinoid receptors, prevented the effects of Δ9-THC but not those of heroin. Naloxone, a generic opioid antagonist, administered systemically, or naloxonazine, an antagonist of μ1 opioid receptors, infused into the ventral tegmentum, prevented the action of cannabinoids and heroin on dopamine transmission. Thus, Δ9-THC and heroin exert similar effects on mesolimbic dopamine transmission through a common μ1 oploid receptor mechanism located in the ventral mesencephalic tegmentum.

Original languageEnglish
Pages (from-to)2048-2050
Number of pages3
JournalScience
Volume276
Issue number5321
DOIs
Publication statusPublished - Jun 27 1997

ASJC Scopus subject areas

  • General

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