Cannabinoid-induced effects on the nociceptive system

A neurophysiological study in patients with secondary progressive multiple sclerosis

Antonella Conte, Chiara Marini Bettolo, Emanuela Onesti, Vittorio Frasca, Elisa Iacovelli, Francesca Gilio, Elena Giacomelli, Maria Gabriele, Massimiliano Aragona, Valentina Tomassini, Patrizia Pantano, Carlo Pozzilli, Maurizio Inghilleri

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Although clinical studies show that cannabinoids improve central pain in patients with multiple sclerosis (MS) neurophysiological studies are lacking to investigate whether they also suppress these patients' electrophysiological responses to noxious stimulation. The flexion reflex (FR) in humans is a widely used technique for assessing the pain threshold and for studying spinal and supraspinal pain pathways and the neurotransmitter system involved in pain control. In a randomized, double-blind, placebo-controlled, cross-over study we investigated cannabinoid-induced changes in RIII reflex variables (threshold, latency and area) in a group of 18 patients with secondary progressive MS. To investigate whether cannabinoids act indirectly on the nociceptive reflex by modulating lower motoneuron excitability we also evaluated the H-reflex size after tibial nerve stimulation and calculated the H wave/M wave (H/M) ratio. Of the 18 patients recruited and randomized 17 completed the study. After patients used a commercial delta-9-tetrahydrocannabinol (THC) and cannabidiol mixture as an oromucosal spray the RIII reflex threshold increased and RIII reflex area decreased. The visual analogue scale score for pain also decreased, though not significantly. Conversely, the H/M ratio measured before patients received cannabinoids remained unchanged after therapy. In conclusion, the cannabinoid-induced changes in the RIII reflex threshold and area in patients with MS provide objective neurophysiological evidence that cannabinoids modulate the nociceptive system in patients with MS.

Original languageEnglish
Pages (from-to)472-477
Number of pages6
JournalEuropean Journal of Pain (United Kingdom)
Volume13
Issue number5
DOIs
Publication statusPublished - May 2009

Fingerprint

Chronic Progressive Multiple Sclerosis
Cannabinoids
Reflex
Multiple Sclerosis
Pain
Cannabidiol
H-Reflex
Abnormal Reflexes
Tibial Nerve
Pain Threshold
Dronabinol
Motor Neurons
Pain Measurement
Cross-Over Studies
Neurotransmitter Agents
Placebos

Keywords

  • Cannabinoids
  • Multiple sclerosis
  • Nociceptive system
  • RIII reflex

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Cannabinoid-induced effects on the nociceptive system : A neurophysiological study in patients with secondary progressive multiple sclerosis. / Conte, Antonella; Bettolo, Chiara Marini; Onesti, Emanuela; Frasca, Vittorio; Iacovelli, Elisa; Gilio, Francesca; Giacomelli, Elena; Gabriele, Maria; Aragona, Massimiliano; Tomassini, Valentina; Pantano, Patrizia; Pozzilli, Carlo; Inghilleri, Maurizio.

In: European Journal of Pain (United Kingdom), Vol. 13, No. 5, 05.2009, p. 472-477.

Research output: Contribution to journalArticle

Conte, A, Bettolo, CM, Onesti, E, Frasca, V, Iacovelli, E, Gilio, F, Giacomelli, E, Gabriele, M, Aragona, M, Tomassini, V, Pantano, P, Pozzilli, C & Inghilleri, M 2009, 'Cannabinoid-induced effects on the nociceptive system: A neurophysiological study in patients with secondary progressive multiple sclerosis', European Journal of Pain (United Kingdom), vol. 13, no. 5, pp. 472-477. https://doi.org/10.1016/j.ejpain.2008.05.014
Conte, Antonella ; Bettolo, Chiara Marini ; Onesti, Emanuela ; Frasca, Vittorio ; Iacovelli, Elisa ; Gilio, Francesca ; Giacomelli, Elena ; Gabriele, Maria ; Aragona, Massimiliano ; Tomassini, Valentina ; Pantano, Patrizia ; Pozzilli, Carlo ; Inghilleri, Maurizio. / Cannabinoid-induced effects on the nociceptive system : A neurophysiological study in patients with secondary progressive multiple sclerosis. In: European Journal of Pain (United Kingdom). 2009 ; Vol. 13, No. 5. pp. 472-477.
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