TY - JOUR
T1 - Canrenone on cardiovascular mortality in congestive heart failure
T2 - CanrenOne eFFects on cardiovascular mortality in patiEnts with congEstIve hearT failure: The COFFEE-IT study
AU - Derosa, Giuseppe
AU - Maffioli, Pamela
AU - Scelsi, Laura
AU - Bestetti, Alessandro
AU - Vanasia, Massimo
AU - Cicero, Arrigo F G
AU - Spinardi, Luca
AU - Bentivenga, Crescenzio
AU - Esposti, Daniela Degli
AU - Caprio, Massimiliano
AU - Borghi, Claudio
AU - Pitt, Bertram
AU - Cosentino, Eugenio
N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.
PY - 2018/11/28
Y1 - 2018/11/28
N2 - AIM: To evaluate canrenone effects compared to other therapies on cardiovascular mortality in patients with chronic heart failure (CHF) and preserved systolic function after 10 years of evaluation.METHODS: We enrolled 532 patients with CHF and preserved systolic function. Patients were followed with a mean follow-up of 10 years: 166 patients were in therapy with canrenone, while 336 patients were in conventional therapy. We re-evaluated these data after 10 years, together with the rate of death and survival.RESULTS: Systolic and diastolic blood pressure were lower with canrenone compared to the group not treated with canrenone, both in supine and orthostatism. In the group treated with canrenone we recorded a lower value of fasting plasma glucose and glycated hemoglobin. Uric acid was lower in the group treated with canrenone, no differences were observed regarding creatinine, sodium, potassium, brain natriuretic peptide (BNP), pro-BNP or plasma renin activity (PRA), while aldosterone levels were reduced in canrenone group compared to control. After 10 years, left ventricular mass was lower in canrenone group. We recorded a more pronounced progression of NYHA class in controls compared to patients treated with canrenone, with also a higher number of deaths. A higher number of deaths was recorded in control group in the 68-83 years range compared to canrenone. A higher incidence of death was reported among patients without hypercholesterolemia in control group; this was not significant in patients treated with canrenone. A longer survival was observed in patients treated with canrenone.CONCLUSION: Administered to patients with CHF and preserved systolic fraction, reduced mortality and extended the life.
AB - AIM: To evaluate canrenone effects compared to other therapies on cardiovascular mortality in patients with chronic heart failure (CHF) and preserved systolic function after 10 years of evaluation.METHODS: We enrolled 532 patients with CHF and preserved systolic function. Patients were followed with a mean follow-up of 10 years: 166 patients were in therapy with canrenone, while 336 patients were in conventional therapy. We re-evaluated these data after 10 years, together with the rate of death and survival.RESULTS: Systolic and diastolic blood pressure were lower with canrenone compared to the group not treated with canrenone, both in supine and orthostatism. In the group treated with canrenone we recorded a lower value of fasting plasma glucose and glycated hemoglobin. Uric acid was lower in the group treated with canrenone, no differences were observed regarding creatinine, sodium, potassium, brain natriuretic peptide (BNP), pro-BNP or plasma renin activity (PRA), while aldosterone levels were reduced in canrenone group compared to control. After 10 years, left ventricular mass was lower in canrenone group. We recorded a more pronounced progression of NYHA class in controls compared to patients treated with canrenone, with also a higher number of deaths. A higher number of deaths was recorded in control group in the 68-83 years range compared to canrenone. A higher incidence of death was reported among patients without hypercholesterolemia in control group; this was not significant in patients treated with canrenone. A longer survival was observed in patients treated with canrenone.CONCLUSION: Administered to patients with CHF and preserved systolic fraction, reduced mortality and extended the life.
U2 - 10.1016/j.phrs.2018.11.037
DO - 10.1016/j.phrs.2018.11.037
M3 - Article
C2 - 30502530
VL - 141
SP - 46
EP - 52
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
ER -