TY - JOUR
T1 - Capsaicin-induced recovery of voiding in patients with idiopathic non-neurological chronic urinary retention
AU - Lazzeri, M.
AU - Beneforti, P.
AU - Turini, D.
PY - 1999
Y1 - 1999
N2 - The therapy of idiopathic non-obstructive non-neurological chronic urinary retention remains unsatisfactory notwithstanding that recently the selective S3 root neural stimulation has been demonstrated to be a promising treatment modality in a selected group of patients. On the basis of our previous experiences we decided to test the hypothesis to use low dosage of intravesical capsaicin to obtain the recovery of voiding in patients with chronic idiopathic non-neurological urinary retention. Nine patients, who presented with a chronic urinary retention for a period longer than 1 year, underwent, during filling cystometrogram, intravesical instillation of 30 ml or a saline solution containing 10-5M capsaicin (Sigma), at a volume 300 ml, as a provocative test to produce a contractile response. After this test they received 50 ml of a saline solution containing 10-5M of capsaicin twice weekly for a month. Voiding pattern and urine residue were evaluated at the end of the study, and an urodynamic assessment was performed after 60 days. Intravesical capsaicin, used as a provocative test, produced a reflex contractile activity of the smooth muscle of the bladder at 300 ml of filling and a reduction of bladder capacity in five patients. At 60-day follow-up six patients reported an improvement of their urinary symptoms. Three patients, who previously partially emptied their bladder and two, who used the clean intermittent catheterization, voided spontaneously. Urine residue was significantly reduced from 237.5 ml±54.39 to 61.66±46.22 (p
AB - The therapy of idiopathic non-obstructive non-neurological chronic urinary retention remains unsatisfactory notwithstanding that recently the selective S3 root neural stimulation has been demonstrated to be a promising treatment modality in a selected group of patients. On the basis of our previous experiences we decided to test the hypothesis to use low dosage of intravesical capsaicin to obtain the recovery of voiding in patients with chronic idiopathic non-neurological urinary retention. Nine patients, who presented with a chronic urinary retention for a period longer than 1 year, underwent, during filling cystometrogram, intravesical instillation of 30 ml or a saline solution containing 10-5M capsaicin (Sigma), at a volume 300 ml, as a provocative test to produce a contractile response. After this test they received 50 ml of a saline solution containing 10-5M of capsaicin twice weekly for a month. Voiding pattern and urine residue were evaluated at the end of the study, and an urodynamic assessment was performed after 60 days. Intravesical capsaicin, used as a provocative test, produced a reflex contractile activity of the smooth muscle of the bladder at 300 ml of filling and a reduction of bladder capacity in five patients. At 60-day follow-up six patients reported an improvement of their urinary symptoms. Three patients, who previously partially emptied their bladder and two, who used the clean intermittent catheterization, voided spontaneously. Urine residue was significantly reduced from 237.5 ml±54.39 to 61.66±46.22 (p
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M3 - Article
AN - SCOPUS:0033277646
VL - 9
SP - 150
EP - 155
JO - Urodinamica
JF - Urodinamica
SN - 1120-5989
IS - 3
ER -